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The Place of X-ray Endovascular Catheter Technologies Taking into Account Errors in the Diagnostic and Treatment Algorithm of Patients with Mediastinal Tumors

Received: 26 September 2021     Accepted: 20 October 2021     Published: 30 October 2021
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Abstract

The purpose of the study. Increase the effectiveness of treatment of patients with epithelial tumors of the mediastinum by using intra-arterial chemoembolization as a neoadjuvant therapy to create ischemia and high concentrations of cytostatics in tumors for a long period of time to achieve devitalization of tumor tissue and reduce overall toxicity of chemotherapy. Object of study. Epithelial tumors of the thymus gland. Research methods: Clinical, laboratory, morphological, instrumental, statistical. Laboratory tests will include general clinical blood tests, biochemical parameters (ALT, AST, bilirubin, alkaline phosphatase, gammaglutamine transpeptidase, lactate dehydrogenase, albumin), biochemical markers of thymus tumor (AFP, HGT), acetylcholine. General blood test (hemoglobin, erythrocytes, leukocytes, platelets). Instrumental methods of examination will include CT (computed tomography) with intravenous contrast, MRI (magnetic resonance imaging). The conclusions can be made from the literature review. It can be stated that there is no common view on the diagnosis and choice of treatment tactics for patients with epithelial tumors of the thymus. Histological heterogeneity of tumors of this anatomical region with the similarity of clinical manifestations and radiological symptoms requires the development of algorithms for their differential diagnosis and optimization of treatment. In addition, over the last decade in Ukraine there has been a significant increase in the number of mediastinal tumors, especially the thymus gland. Given mainly the young age of patients with this disease and the high degree of aggressiveness of the disease, the problem is transformed to the social level. It is also necessary to review the traditional approach to the treatment of this pathology, the first link of which is considered to be surgery.

Published in American Journal of Biomedical and Life Sciences (Volume 9, Issue 5)
DOI 10.11648/j.ajbls.20210905.18
Page(s) 271-278
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Combination Treatment, Endovascular Technologies, Risk of Metastasis, Intra-arterial Chemoembolization, Regional (Selective) Chemotherapy, Thymoma Formation - Thymoma, Superior Vena Cava Syndrome

References
[1] NCCN Guidelines. Version 1.2020. Thymomas and Thymic Carcinomas.
[2] Ганул А. В. Оптимизация диагностики и лечения пациентов со злокачественными опухолями средостения. Онкология. [Optimization of diagnosis and treatmet of patients with malignant mediastinal tumors. Oncology.] - 2009, т. 11, №2- С. 131-135.
[3] Борисюк Б. О. Внутриартериальная регионарная полихимиотерапия при комплексном лечении злокачественных новообразований средостения. Онкология. [Intra-arterial regional polychemotherapy in the complex treatment of malignant neoplasms of the mediastinum. Oncology]. - 2009, т. 11, №2- С. 136-138.
[4] Александров О. А. Тимома (обзор литературы) [Timoma (literature review)] / О. А. Александров, А. Б. Рябов, О. В. Пикин // Сибирский онкологический журнал. [Siberian Journal of Oncology.] – 2017. – Т. 16. -№4. – С. 76–83.
[5] Александров О. А. Трансторакальная толстоигольная биопсия опухолей средостения под контролем ультразвуковой навигации [Transthoracic thickneedle biopsy of mediastinal tumors under the control of ultrasound navigation.] / О. А. Александров, С. О. Степанов, О. В. Пикин, Н. Н. Волченко, В. Соловьев, П. Д. Беспалов, Д. А. Вурсол // Онкология. Журнал им. П. А. Герцена. [Oncology. Journal by P. A. Herzen.] – 2019. – Том 8, №2. – С. 88-93.
[6] Алексеева Т. М. Клинико-иммунологические особенности миастении и подходы к ее терапии у лиц пожилого возраста (обзор литературы)[Clinical and immunological features of myasthenia gravis and approaches to its therapy in the ederly (literature review)] / Т. М. Алексеева, В. Д. Косачев, А. Н. Халмурзина // Нервно-мышечные болезни. [Neuromuscular diseases]– 2016. – Т. 6.- №3. – С. 10-16.
[7] Интервенционная радиология в онкологии (пути развития и технологии): научно-практическое издание [Interventional radiology in oncology (ways of development and technologies): scientific and practical edition]/ гл. ред.: А. М. Гранов, М. И. Давыдов; ред.: П. Г. Таразов, Д. А. Гранов, Б. И. Долгушин, В. Н. Полысалов, А. А. Поликарпов. –2007. – 344 с.
[8] Борисова Т. Н. Клинические рекомендации по диагностике и лечению больных опухолями средостения и вилочковой железы/[Clinical guidelines for the diagnosis and treatment of patients with tumors of the mediastinum and thymus] Т. Н. Борисова, В. В. Бредер, В. А. Горбунова, С. М. Иванов.- 2014.- с. 64.
[9] Кудрявцев А. С. Робот-ассистированные вмешательства в торакальной хирургии (первый опыт) [Robot-assisted interventions in thoracic surgery (the first experience)]/ А. С. Кудрявцев, С. В. Ярмощук, Е. А. Дробзягин, А. Н. Архипов // Сибирский Научный Медицинский Журнал. [Siberian Scientific Medical Journal]- Т. 35.- № 6.- 2015.- С. 56-59.
[10] Руководство по химиотерапии опухолевых заболеваний. Издание 4-е [Guidelines for the chemotherapy of neoplastic diseases. The 4th edition.] Переводчикова Н. И., Горбунова В. А. (под ред.) Изд. «Практическая медицина» [(edited by) Publ. Practical Medicine], 2015. —688 с.
[11] Курганов И. А. Роль и место малоинвазивных хирургических технологий в лечении заболеваний вилочковой железы The role and place of minimally invasive surgical technologies in the treatment of diseases of the thymus gland/ И. А. Курганов, Д. Ю. Богданов // Эндоскопическая хирургия. Endoscopic surgery– 2013. -№6. – С. 49-54.
[12] Сигал Е. И. Результаты видеоторакоскопической тимэктомии у пациентов с миастенией в сочетании с опухолевой патологией вилочковой железы [Results of videothoracoscopic thymectomy in patients with tumor pathology of the thymus gland]/ Е. И. Сигал, Р. Е. Сигал, А. М. Сигал, М. В. Бурмистров // Поволжский онкологический вестник. [Povolzhsky Oncological Journal] – 2015. - №2. – С. 11-17.
[13] Ю. В. Авдосьєв, І. В. Белозьоров/ Інтервенційна радіологія в онкології [Interventional radiology in oncology]- 2020.- P. 170-174.
[14] Achey, R. L. Rare thymoma metastases to the spine: case reports and review of the literature // R. L. Achey, B. S. Lee, S. Sundar, E. C. et al. // World Neurosurg. – 2018. – Vol. 110. – P. 423-431.
[15] Bleetman D. Video-assisted thoracoscopic thymectomy / D. Bleetman, D. West, E. Teh, E. Internullo // Annals of Cardiothoracic Surgery. – 2015. – Vol. 4.-№ 6. – P. 556-557.
[16] Cheng Y. J. Videothoracoscopic resection of stage II thymoma: prospective comparison of the results between thoracoscopy and open methods/ Y. J. Cheng, E. L. Kao, S. H. Chou// Chest.- 2015.-№128.-P. 3010-3012.
[17] Den Bakker M. A. Histologic classification of thymoma: a practical guide for routine cases / M. A. den Bakker, A. C. Roden, A. Marx, M. Marino // J. Thorac. Oncol. – 2014. – Vol. 9. – P. 125-S130.
[18] Detterbeck F. C. Thymoma: current diagnosis and treatment / F. C. Detterbeck, A. Zeeshan // Chin. Med. J. – 2013. – Vol. 126, №11.– P. 2186-2191.
[19] Fukui T. Middle mediastinal thymoma / T. Fukui, R. Sumitomo, Y. Otake, C. L. Huang // Ann. Thorac. Surg. – 2018. – Vol. 106, №4. – P. 189-191.
[20] Fukushima Т. Successful salvage chemotherapy with amrubicin for invasive thymoma associated with myasthenia gravis / T. Fukushima, D. Gomi, T. Kobayashi, N. Sekiguchi, A. Sakamoto, S. Sasaki, T. Koizumi // Japanese Journal of Clinical Oncology. – 2014. - Vol.-44, N. 11. - P. 1120-1122.
[21] Gentili F. Update in diagnostic imaging of the thymus and anterior mediastinal masses / F. Gentili, V. Pelini, G. Lucii et al. // Gland Surg. – 2019. – Vol. 8 (Suppl. 3). – P. 188-S207.
[22] Girard N. Thymic epithelial tumours: ESMO clinical practice guidelines for diagnosis, treatment and follow-up / N. Girard, E. Ruffini, A. Marx, C. Faivre-Finn, S. Peters // Annals of Oncology. – 2015. – Vol. – 26, N. 5. – Р. 40–55.
[23] Goldstein A. J. A tour of the thymus: a review of thymic lesions with radiologic and pathologic correlation / A. J. Goldstein, I. Oliva, H. Honarpishen, A. Rubinowitz // Canadian Association of Radiologist Journal. – 2015. – Vol. 66, Issue1. – P. 5-15
[24] Gong L. World Health Organization type B2 thymoma with an abundance of Hassall s corpuscles: a case report / L. Gong, L. Sun, C. Zhang et al. // Oncol. Lett. – 2018. Vol. 15, №6. – P. 9283-9286.
[25] Guleria P. PD-L1 immuno-expression assay in thymomas: Study of 84 cases and review of literature / N. Husain, S. Shukla, S. Kumar et al. // Ann. Diagn. Pathol. – 2018. – Vol. 34. – P. 135-141.
[26] Hakiri S. Clinicopathologic features of thymoma with the expression of programmed death ligand 1 / S. Hakiri, T. Fukui, S. Mori et al. // Ann. Thorac. Surg. – 2019. – Vol. 107, №2. – P. 418-424.
[27] Hamaji M. A meta-analysis of debulking surgery versus surgical biopsy for unresectable thymoma / M. Hamaji, F. Kojima, M. Omasa, T. Sozub // European Journal of Cardio-Thoracic Surgery. – 2015. – Vol. 47. – P. 602–607.
[28] Hess N. R. Minimally invasive versus open thymectomy: a systematic review of surgical techniques, patient demographics, and perioperative outcomes / N. R. Hess, I. Sarkaria, A. Pennathur, R. M. Levy //Annals of Cardiothoracic Surgery. – 2016. – Vol. 5.-№1. – P. 1-9.
[29] Huang J. A new staging system for thymoma—will it improve outcomes? / J. Huang // The Journal of Thoracic and Cardiovascular Surgery. - 2015. - Vol. 51.-№ 1. - P. 20–22.
[30] Huang Р. Solitary metastasis to the breast after complete resection of encapsulated type AB thymoma: a case report / P. W. Huang, K. M. Chang // Journal of Medical Case Reports. – 2015. – Vol. – 9. – P. 1-5.
[31] Jamilloux Y. Thymoma and autoimmune disease / Y. Jamilloux, H. Frih, C. Bernard et al. / Rev. Med. Interne. – 2018. – Vol. 39, №1. – P. 17-26.
[32] Kaba Е. Role of surgery in the treatment of Masaoka stage IVa thymoma / E. Kaba, B. Ozkan, S. Erus, S. Duman // Annals of Thoracic and Cardiovascular Surgery. – 2017. - Vol. 24.-№1. – P. 6-12.
[33] Leuzzi G. Multimodality therapy for locally advanced thymomas: A propensity score–matched cohort study from the European Society of Thoracic Surgeons Database / G. Leuzzi, G. Rocco, E. Ruffini, I. Sperduti, F. Detterbeck, W. Weder, F. Venuta, D. V. Raemdonck, P. Thomas, F. Facciolo // The Journal of Thoracic and Cardiovascular Surgery. – 2015. - Vol. - 151, N. 1. – Р. 47–57.
[34] Li Х. Preoperative misdiagnosis analysis and accurate distinguish intrathymic cyst from small thymoma on computed tomography / X. Li, X. Han, W. Sun, M. Wang, G. Jing, X. Zhang// Journal of Thoracic Disease. - 2016. - Vol. - 8, N. 8. - Р. 2086-2092.
[35] Liu Z. Unilateral video-assisted thoracoscopic extended thymectomy offers long-term outcomes equivalent to that of the bilateral approach in the treatment of non-thymomatous myasthenia gravis/ Z. Liu, J. Yang, L. Lin// Interact. Cardiovasc. Thorac. Surg.- 2015.-№21.- P. 610-615.
[36] Lushina N. Outpatient video-assisted thoracoscopic thymectomy in an octogenarian / N. Lushina, C. F. Hynes, M. B. Marshall // Journal of Visualized Surgery. – 2016. – Vol. 2.-№ 168. – P. 1-3.
[37] Marx A. The 2015 World Health Organization classification of tumors of the thymus / A. Marx, J. K. C. Chan, J. M. Coindre, F. Detterbeck // Journal of Thoracic Oncology. – 2015. – Vol. 10.-№10. – P. 1383-1395.
[38] Matilla J. R. Thymic minimally invasive surgery: state of the art across the world—Europe / J. R. Matilla, W. Klepetko, B. Moser // Journal of Visualized Surgery. – 2017. – Vol. 3.-№. 70. – P. 1-6.
[39] Melfi F. M. Minimally invasive mediastinal surgery// Melfi F. M., Fanucchi O., Mussi A. // Ann. Cardiothoracic Surg. – 2016. - Vol 5.-№1.-P. 10-17.
[40] Park N. O. Ectopic cervical thymoma: a case report and review / N. O. Park, S. H. Kim, S. H. Moon et al. // Korean J. Thorac. Cardivasc. Surg. – 2017. – Vol. 50, №4. – P. 312-315.
[41] Scorsetti M. Thymoma and thymic carcinoma / M. Scorsetti, F. Leo, A. Trama, et al. // Critical Reviews in Oncology/Hematology. – 2016. – Vol. 99. – P. 332-350.
[42] Shen J. Jnter-relationship among myasthenia gravis, WHO histology, and Masaoka clinical stage and effect on surgical methods in patients with thymoma: a retrospective cohort study / J. Shen, H. Tie, A. Xu et al. // J. Thorac. Dis. – 2018. – Vol. 10, №5. – P. 2981-2990.
[43] Speisky D. Hepatic metastasis of thymoma: case report and immunohistochemical study / D. Speisky, M. T. G. de Davila, F. Vigovich, J. Mendez, R. Maurette, M. G. Ejarque, J. C. Spina, A. Iotti, P. Dezanzo // Ecancer. - 2016. – Vol. 10. N. 693. – Р. 1-6.
[44] Su X.-Y. Immunohistochemical differentiation between type B3 thymomas and thymic squamous cell carcinomas / X.-Y. Su, W.-Y. Wang, J.-N. Li.// Int. J. Clin. Exp. Pathol. – 2015. – Vol. 8, №5. – P. 5354-5362.
[45] Tassi V. Could thymomectomy be a reasonable option for non-myasthenic thymoma patients? / V. Tassi, S. Ceccarelli, C. Zannori, A. Gili, N. Daddi, G. Bellezza, S. Ascani, A. M. Liberati, F. Puma // Journal of Thoracic Disease. - 2017. - Vol. 9, N. 10. – P. 3817-3824.
[46] Uchio N. Inflammatory myopathy with myasthenia gravis: thymoma association and polymyositis pathology / N. Uchio, K. Taira, C. Ikenaga et al. // Neurol. Neuroimmunol. Neuroinflamm. – 2018. – Vol. 6, №2. – P. 535.
[47] Wu J. The enlightenments from ITMIG Consensus on WHO histological classification of thymoma and thymic carcinoma: refined definitions, histological criteria, and reporting / J. Wu, W. Fang, G. Chen // J. Thorac. Dis. – 2016. – Vol. 8, №4. – P. 738-743.
[48] Dinkel H. P. Endovascular treatment of malignant superior vena cava syndrome: is bilateral Wallstent placement superior to unilateral placement? / H. P. Dinkel, B. Mettke, F. Schmid et al. // J. Endovasc. Ther. – 2003. – Vol. 10. – P. 788–797.
[49] Jaretzki A. Thymectomy for myasthenia gravis: analysis of controversies patient management / A. Jaretzki // Neurologist. – 2003. — Vol. 9. –P. 77–92.
[50] Mack M. J. Video-assisted thoracoscopy thymectomy for myasthenia gravis II / M. J. Mack // Chest Surg. Clin. N. Am. 2001. – Vol. 11, № 2. – P. 389–406.
[51] Masaoka A. Extended transsternal thymectomy for myasthenia gravis / A. Masaoka // Chest Surg. Clin. N. Am. – 2001. – №2. – P. 369–387.
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    Kravchenko Roman Yuriyovych, Avdosyev Yuriy Volodymyrovych, Oleh Mykolayovych Luzan, Yakiv Ivanovych Ivashchik. (2021). The Place of X-ray Endovascular Catheter Technologies Taking into Account Errors in the Diagnostic and Treatment Algorithm of Patients with Mediastinal Tumors. American Journal of Biomedical and Life Sciences, 9(5), 271-278. https://doi.org/10.11648/j.ajbls.20210905.18

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    ACS Style

    Kravchenko Roman Yuriyovych; Avdosyev Yuriy Volodymyrovych; Oleh Mykolayovych Luzan; Yakiv Ivanovych Ivashchik. The Place of X-ray Endovascular Catheter Technologies Taking into Account Errors in the Diagnostic and Treatment Algorithm of Patients with Mediastinal Tumors. Am. J. Biomed. Life Sci. 2021, 9(5), 271-278. doi: 10.11648/j.ajbls.20210905.18

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    AMA Style

    Kravchenko Roman Yuriyovych, Avdosyev Yuriy Volodymyrovych, Oleh Mykolayovych Luzan, Yakiv Ivanovych Ivashchik. The Place of X-ray Endovascular Catheter Technologies Taking into Account Errors in the Diagnostic and Treatment Algorithm of Patients with Mediastinal Tumors. Am J Biomed Life Sci. 2021;9(5):271-278. doi: 10.11648/j.ajbls.20210905.18

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  • @article{10.11648/j.ajbls.20210905.18,
      author = {Kravchenko Roman Yuriyovych and Avdosyev Yuriy Volodymyrovych and Oleh Mykolayovych Luzan and Yakiv Ivanovych Ivashchik},
      title = {The Place of X-ray Endovascular Catheter Technologies Taking into Account Errors in the Diagnostic and Treatment Algorithm of Patients with Mediastinal Tumors},
      journal = {American Journal of Biomedical and Life Sciences},
      volume = {9},
      number = {5},
      pages = {271-278},
      doi = {10.11648/j.ajbls.20210905.18},
      url = {https://doi.org/10.11648/j.ajbls.20210905.18},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20210905.18},
      abstract = {The purpose of the study. Increase the effectiveness of treatment of patients with epithelial tumors of the mediastinum by using intra-arterial chemoembolization as a neoadjuvant therapy to create ischemia and high concentrations of cytostatics in tumors for a long period of time to achieve devitalization of tumor tissue and reduce overall toxicity of chemotherapy. Object of study. Epithelial tumors of the thymus gland. Research methods: Clinical, laboratory, morphological, instrumental, statistical. Laboratory tests will include general clinical blood tests, biochemical parameters (ALT, AST, bilirubin, alkaline phosphatase, gammaglutamine transpeptidase, lactate dehydrogenase, albumin), biochemical markers of thymus tumor (AFP, HGT), acetylcholine. General blood test (hemoglobin, erythrocytes, leukocytes, platelets). Instrumental methods of examination will include CT (computed tomography) with intravenous contrast, MRI (magnetic resonance imaging). The conclusions can be made from the literature review. It can be stated that there is no common view on the diagnosis and choice of treatment tactics for patients with epithelial tumors of the thymus. Histological heterogeneity of tumors of this anatomical region with the similarity of clinical manifestations and radiological symptoms requires the development of algorithms for their differential diagnosis and optimization of treatment. In addition, over the last decade in Ukraine there has been a significant increase in the number of mediastinal tumors, especially the thymus gland. Given mainly the young age of patients with this disease and the high degree of aggressiveness of the disease, the problem is transformed to the social level. It is also necessary to review the traditional approach to the treatment of this pathology, the first link of which is considered to be surgery.},
     year = {2021}
    }
    

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  • TY  - JOUR
    T1  - The Place of X-ray Endovascular Catheter Technologies Taking into Account Errors in the Diagnostic and Treatment Algorithm of Patients with Mediastinal Tumors
    AU  - Kravchenko Roman Yuriyovych
    AU  - Avdosyev Yuriy Volodymyrovych
    AU  - Oleh Mykolayovych Luzan
    AU  - Yakiv Ivanovych Ivashchik
    Y1  - 2021/10/30
    PY  - 2021
    N1  - https://doi.org/10.11648/j.ajbls.20210905.18
    DO  - 10.11648/j.ajbls.20210905.18
    T2  - American Journal of Biomedical and Life Sciences
    JF  - American Journal of Biomedical and Life Sciences
    JO  - American Journal of Biomedical and Life Sciences
    SP  - 271
    EP  - 278
    PB  - Science Publishing Group
    SN  - 2330-880X
    UR  - https://doi.org/10.11648/j.ajbls.20210905.18
    AB  - The purpose of the study. Increase the effectiveness of treatment of patients with epithelial tumors of the mediastinum by using intra-arterial chemoembolization as a neoadjuvant therapy to create ischemia and high concentrations of cytostatics in tumors for a long period of time to achieve devitalization of tumor tissue and reduce overall toxicity of chemotherapy. Object of study. Epithelial tumors of the thymus gland. Research methods: Clinical, laboratory, morphological, instrumental, statistical. Laboratory tests will include general clinical blood tests, biochemical parameters (ALT, AST, bilirubin, alkaline phosphatase, gammaglutamine transpeptidase, lactate dehydrogenase, albumin), biochemical markers of thymus tumor (AFP, HGT), acetylcholine. General blood test (hemoglobin, erythrocytes, leukocytes, platelets). Instrumental methods of examination will include CT (computed tomography) with intravenous contrast, MRI (magnetic resonance imaging). The conclusions can be made from the literature review. It can be stated that there is no common view on the diagnosis and choice of treatment tactics for patients with epithelial tumors of the thymus. Histological heterogeneity of tumors of this anatomical region with the similarity of clinical manifestations and radiological symptoms requires the development of algorithms for their differential diagnosis and optimization of treatment. In addition, over the last decade in Ukraine there has been a significant increase in the number of mediastinal tumors, especially the thymus gland. Given mainly the young age of patients with this disease and the high degree of aggressiveness of the disease, the problem is transformed to the social level. It is also necessary to review the traditional approach to the treatment of this pathology, the first link of which is considered to be surgery.
    VL  - 9
    IS  - 5
    ER  - 

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Author Information
  • Department of Oncology and Pediatric Oncology of KhMAPE, Chernihiv Regional Hospital, Chernihiv, Ukraine

  • Department of Oncology and Pediatric Oncology of KhMAPE, Chernihiv Regional Hospital, Chernihiv, Ukraine

  • The Surgical Thoracic Department, Chernihiv Regional Hospital, Chernihiv, Ukraine

  • The Surgical Thoracic Department, Chernihiv Regional Hospital, Chernihiv, Ukraine

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