Sezary Syndrome: A Clinico-biological Study of 5 Cases

Rania Rada; Hajar Saffour; Mahjouba Baiya; Hicham Yahyaoui; Mustapha Ait Ameur; Mohamed Chakour

doi:doi:10.11648/j.ajbls.20221002.16

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Sezary Syndrome: A Clinico-biological Study of 5 Cases

Rania Rada, Hajar Saffour, Mahjouba Baiya, Hicham Yahyaoui, Mustapha Ait Ameur, Mohamed Chakour

Published in American Journal of Biomedical and Life Sciences (Volume 10, Issue 2)

Received: 12 March 2022 Accepted: 9 April 2022 Published: 20 April 2022

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Abstract

Background: Sézary syndrome (SS) is a rare erythrodermic and leukemic variant of cutaneous T-cell lymphoma (CTCL) that belongs to the group of non-Hodgkin's lymphomas (NHL) resulting from malignant proliferation of skin-homing T cells. We report through a series of 5 cases, the experience of the hematology laboratory in the diagnosis of the syndrome of Sézary. Methods: This is a retrospective study of 5 cases of Sezary syndrome collected in the dermatology department of Marrakech. Results: five patients were identified with the clinicopathological criteria of SS. At the time of diagnosis, all 5 patients had erythroderma and generalized lymphadenopathy in both superficial and deep stations. The white blood cell count was elevated (>10,000 WBC/mm³) in all 5 patients with a mean value of 18,120 WBC/mm³. The blood smear showed the presence of 75% (27 G/l) of small to medium-sized cells with a high nucleocytoplasmic ratio and cerebriform nuclei typical of Sezary cells and suggests the diagnosis of SS. Conclusions: The diagnosis of SS remains a challenge in many situations, the pathophysiology and definition of SS have evolved significantly over the past decades.

Published in	American Journal of Biomedical and Life Sciences (Volume 10, Issue 2)
DOI	10.11648/j.ajbls.20221002.16
Page(s)	42-44
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Sezary Syndrome, Lymphoma, T-cell, Blood Smear

References

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APA Style

Rania Rada, Hajar Saffour, Mahjouba Baiya, Hicham Yahyaoui, Mustapha Ait Ameur, et al. (2022). Sezary Syndrome: A Clinico-biological Study of 5 Cases. American Journal of Biomedical and Life Sciences, 10(2), 42-44. https://doi.org/10.11648/j.ajbls.20221002.16

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ACS Style

Rania Rada; Hajar Saffour; Mahjouba Baiya; Hicham Yahyaoui; Mustapha Ait Ameur, et al. Sezary Syndrome: A Clinico-biological Study of 5 Cases. Am. J. Biomed. Life Sci. 2022, 10(2), 42-44. doi: 10.11648/j.ajbls.20221002.16

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AMA Style

Rania Rada, Hajar Saffour, Mahjouba Baiya, Hicham Yahyaoui, Mustapha Ait Ameur, et al. Sezary Syndrome: A Clinico-biological Study of 5 Cases. Am J Biomed Life Sci. 2022;10(2):42-44. doi: 10.11648/j.ajbls.20221002.16

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@article{10.11648/j.ajbls.20221002.16,
  author = {Rania Rada and Hajar Saffour and Mahjouba Baiya and Hicham Yahyaoui and Mustapha Ait Ameur and Mohamed Chakour},
  title = {Sezary Syndrome: A Clinico-biological Study of 5 Cases},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {10},
  number = {2},
  pages = {42-44},
  doi = {10.11648/j.ajbls.20221002.16},
  url = {https://doi.org/10.11648/j.ajbls.20221002.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20221002.16},
  abstract = {Background: Sézary syndrome (SS) is a rare erythrodermic and leukemic variant of cutaneous T-cell lymphoma (CTCL) that belongs to the group of non-Hodgkin's lymphomas (NHL) resulting from malignant proliferation of skin-homing T cells. We report through a series of 5 cases, the experience of the hematology laboratory in the diagnosis of the syndrome of Sézary. Methods: This is a retrospective study of 5 cases of Sezary syndrome collected in the dermatology department of Marrakech. Results: five patients were identified with the clinicopathological criteria of SS. At the time of diagnosis, all 5 patients had erythroderma and generalized lymphadenopathy in both superficial and deep stations. The white blood cell count was elevated (>10,000 WBC/mm3) in all 5 patients with a mean value of 18,120 WBC/mm3. The blood smear showed the presence of 75% (27 G/l) of small to medium-sized cells with a high nucleocytoplasmic ratio and cerebriform nuclei typical of Sezary cells and suggests the diagnosis of SS. Conclusions: The diagnosis of SS remains a challenge in many situations, the pathophysiology and definition of SS have evolved significantly over the past decades.},
 year = {2022}
}

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TY  - JOUR
T1  - Sezary Syndrome: A Clinico-biological Study of 5 Cases
AU  - Rania Rada
AU  - Hajar Saffour
AU  - Mahjouba Baiya
AU  - Hicham Yahyaoui
AU  - Mustapha Ait Ameur
AU  - Mohamed Chakour
Y1  - 2022/04/20
PY  - 2022
N1  - https://doi.org/10.11648/j.ajbls.20221002.16
DO  - 10.11648/j.ajbls.20221002.16
T2  - American Journal of Biomedical and Life Sciences
JF  - American Journal of Biomedical and Life Sciences
JO  - American Journal of Biomedical and Life Sciences
SP  - 42
EP  - 44
PB  - Science Publishing Group
SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.20221002.16
AB  - Background: Sézary syndrome (SS) is a rare erythrodermic and leukemic variant of cutaneous T-cell lymphoma (CTCL) that belongs to the group of non-Hodgkin's lymphomas (NHL) resulting from malignant proliferation of skin-homing T cells. We report through a series of 5 cases, the experience of the hematology laboratory in the diagnosis of the syndrome of Sézary. Methods: This is a retrospective study of 5 cases of Sezary syndrome collected in the dermatology department of Marrakech. Results: five patients were identified with the clinicopathological criteria of SS. At the time of diagnosis, all 5 patients had erythroderma and generalized lymphadenopathy in both superficial and deep stations. The white blood cell count was elevated (>10,000 WBC/mm3) in all 5 patients with a mean value of 18,120 WBC/mm3. The blood smear showed the presence of 75% (27 G/l) of small to medium-sized cells with a high nucleocytoplasmic ratio and cerebriform nuclei typical of Sezary cells and suggests the diagnosis of SS. Conclusions: The diagnosis of SS remains a challenge in many situations, the pathophysiology and definition of SS have evolved significantly over the past decades.
VL  - 10
IS  - 2
ER  -

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Author Information

Rania Rada

Laboratory of Hematology, Avicenne Military Hospital, Marrakech, Morocco
Hajar Saffour

Laboratory of Hematology, Avicenne Military Hospital, Marrakech, Morocco
Mahjouba Baiya

Laboratory of Hematology, Avicenne Military Hospital, Marrakech, Morocco
Hicham Yahyaoui

Laboratory of Hematology, Avicenne Military Hospital, Marrakech, Morocco
Mustapha Ait Ameur

Laboratory of Hematology, Avicenne Military Hospital, Marrakech, Morocco
Mohamed Chakour

Laboratory of Hematology, Avicenne Military Hospital, Marrakech, Morocco

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APA Style

Rania Rada, Hajar Saffour, Mahjouba Baiya, Hicham Yahyaoui, Mustapha Ait Ameur, et al. (2022). Sezary Syndrome: A Clinico-biological Study of 5 Cases. American Journal of Biomedical and Life Sciences, 10(2), 42-44. https://doi.org/10.11648/j.ajbls.20221002.16

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ACS Style

Rania Rada; Hajar Saffour; Mahjouba Baiya; Hicham Yahyaoui; Mustapha Ait Ameur, et al. Sezary Syndrome: A Clinico-biological Study of 5 Cases. Am. J. Biomed. Life Sci. 2022, 10(2), 42-44. doi: 10.11648/j.ajbls.20221002.16

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AMA Style

Rania Rada, Hajar Saffour, Mahjouba Baiya, Hicham Yahyaoui, Mustapha Ait Ameur, et al. Sezary Syndrome: A Clinico-biological Study of 5 Cases. Am J Biomed Life Sci. 2022;10(2):42-44. doi: 10.11648/j.ajbls.20221002.16

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@article{10.11648/j.ajbls.20221002.16,
  author = {Rania Rada and Hajar Saffour and Mahjouba Baiya and Hicham Yahyaoui and Mustapha Ait Ameur and Mohamed Chakour},
  title = {Sezary Syndrome: A Clinico-biological Study of 5 Cases},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {10},
  number = {2},
  pages = {42-44},
  doi = {10.11648/j.ajbls.20221002.16},
  url = {https://doi.org/10.11648/j.ajbls.20221002.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20221002.16},
  abstract = {Background: Sézary syndrome (SS) is a rare erythrodermic and leukemic variant of cutaneous T-cell lymphoma (CTCL) that belongs to the group of non-Hodgkin's lymphomas (NHL) resulting from malignant proliferation of skin-homing T cells. We report through a series of 5 cases, the experience of the hematology laboratory in the diagnosis of the syndrome of Sézary. Methods: This is a retrospective study of 5 cases of Sezary syndrome collected in the dermatology department of Marrakech. Results: five patients were identified with the clinicopathological criteria of SS. At the time of diagnosis, all 5 patients had erythroderma and generalized lymphadenopathy in both superficial and deep stations. The white blood cell count was elevated (>10,000 WBC/mm3) in all 5 patients with a mean value of 18,120 WBC/mm3. The blood smear showed the presence of 75% (27 G/l) of small to medium-sized cells with a high nucleocytoplasmic ratio and cerebriform nuclei typical of Sezary cells and suggests the diagnosis of SS. Conclusions: The diagnosis of SS remains a challenge in many situations, the pathophysiology and definition of SS have evolved significantly over the past decades.},
 year = {2022}
}

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TY  - JOUR
T1  - Sezary Syndrome: A Clinico-biological Study of 5 Cases
AU  - Rania Rada
AU  - Hajar Saffour
AU  - Mahjouba Baiya
AU  - Hicham Yahyaoui
AU  - Mustapha Ait Ameur
AU  - Mohamed Chakour
Y1  - 2022/04/20
PY  - 2022
N1  - https://doi.org/10.11648/j.ajbls.20221002.16
DO  - 10.11648/j.ajbls.20221002.16
T2  - American Journal of Biomedical and Life Sciences
JF  - American Journal of Biomedical and Life Sciences
JO  - American Journal of Biomedical and Life Sciences
SP  - 42
EP  - 44
PB  - Science Publishing Group
SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.20221002.16
AB  - Background: Sézary syndrome (SS) is a rare erythrodermic and leukemic variant of cutaneous T-cell lymphoma (CTCL) that belongs to the group of non-Hodgkin's lymphomas (NHL) resulting from malignant proliferation of skin-homing T cells. We report through a series of 5 cases, the experience of the hematology laboratory in the diagnosis of the syndrome of Sézary. Methods: This is a retrospective study of 5 cases of Sezary syndrome collected in the dermatology department of Marrakech. Results: five patients were identified with the clinicopathological criteria of SS. At the time of diagnosis, all 5 patients had erythroderma and generalized lymphadenopathy in both superficial and deep stations. The white blood cell count was elevated (>10,000 WBC/mm3) in all 5 patients with a mean value of 18,120 WBC/mm3. The blood smear showed the presence of 75% (27 G/l) of small to medium-sized cells with a high nucleocytoplasmic ratio and cerebriform nuclei typical of Sezary cells and suggests the diagnosis of SS. Conclusions: The diagnosis of SS remains a challenge in many situations, the pathophysiology and definition of SS have evolved significantly over the past decades.
VL  - 10
IS  - 2
ER  -

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