Tumor of the Granulosa of the Ovary About a Case

Zein Ahmed; Ahmedou Moulaye Idriss; Nacer Dine Ould Mohamed Baba; Isselmou Sidi

doi:doi:10.11648/j.ajbls.20221003.14

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Tumor of the Granulosa of the Ovary About a Case

Zein Ahmed, Ahmedou Moulaye Idriss, Nacer Dine Ould Mohamed Baba, Isselmou Sidi

Published in American Journal of Biomedical and Life Sciences (Volume 10, Issue 3)

Received: 18 May 2022 Accepted: 10 June 2022 Published: 27 June 2022

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Abstract

Ovarian granulosa tumors are very rare; they belong to the group of sex cord and stromal tumors. Their slow evolution in the adult forms which are more frequent (95%) and less aggressive than the much rarer juvenile forms. The exact etiology of these tumors is unknown, but higher than normal estrogen levels are frequently found in women with ovarian granulosa cell tumors. A woman's menstrual status with excess estrogen is related to the presence of certain symptoms such as: early puberty in young women, increase in the size of the abdomen, menstrual cycle disorders in pre menopause or bleeding abnormal uteri in postmenopausal women. The most frequent ultrasound aspect is the solid-cystic aspect and pathological examination remains the diagnostic key. The treatment is essentially surgical, but sometimes associated with complementary therapies such as: chemotherapy, radiotherapy, hormone therapy. Recurrences occur late, hence the importance of post-therapeutic follow-up. Some aggressive forms relapse and progress more rapidly, which justifies rigorous therapeutic monitoring. The prognostic factors for recurrence identified in the literature are the FIGO stage, the presence of residual tumor and the tumor size. We report a case of observation and we draw attention to the epidemiological, clinical particularities, as well as the various prognostic factors in order to carry out a better therapeutic management.

Published in	American Journal of Biomedical and Life Sciences (Volume 10, Issue 3)
DOI	10.11648/j.ajbls.20221003.14
Page(s)	81-83
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Ovary, Adult, Granulosa, Tumour

References

[1]	Park JY, Jin KL, Kim DY, Kim JH, Kim YM, Kim KR et al. Surgical staging and adjuvant chemotherapy in the menehment of patients with adult granulose cell tumors of the ovary. Gynecol Oncol. 2012; 125 (1): 80-6. PubMed \|Google scholar.
[2]	Bompas E, Freyer G, Vitrey D, Trillet-lenoir V, tumeur à cellules de la granulosa: revue de la littérature. Bull Cancer 2000; 87: 709-14.
[3]	Lauszus FF, Petersen AC, Greisen G, Jakobsen A. Granulosa cell tumor of the ovary: a population - based study of 37 women with stage \| disease. Gynecol Oncol, 2001 Jun; 81 (3): 456-60. pubmed\|Google scholar.
[4]	Tavassoli FA, Monney E, Gersell DJ, McCluggage WG, Konishi I, Fujii S, et al. sex cord-stromal tumors. In: Tavassoli FA, Devilee P, des. World health organisation classification of tumors, pathology & Genetics tumor of the beast and female genital organs. Lyon: IARC press 2003: p. 146-61. PubMed \| Google scholar.
[5]	Evans AT, Gaffey TA, Malkasian GD, Annegers JF. clinicopathologic review of the 118 granulosa and 82 theca cel tumors. Obstet Gynecol 1980; 55: 2 31-8.
[6]	Norris HJ, Taylor HB. Prognosis of granulosa-theca cell tumors of the ovary. Cancer 1968; 21: 255-63.
[7]	Bjorkholm E, Pettersson F. Granulosa and theca-cell tumors; the clinical picture and long- term outcome for the radium-hemnet series. Acta Obstet Gynecol Scand 1980; 59: 361-5.
[8]	Schweppe KW, Beller FK. Clinical data of granulosa cell tumors. J Cancer Res Cli Oncol 1982; 104: 161-9.
[9]	Unkila-kallio L, Titinen A, Walhstrom T et al. Reproductive features in women developing ovarian granulosa cell tumour at a fertile age. Hum Reprod 2000; 15: 589-93.
[10]	Zeghal Souki D, Bouchahda H, Kehila M, Mahjoub S. Les tumeurs de la granulosa: à propos de 7 cas. La tunisie Medicale, 2011; 89 (1): 43 – 46.
[11]	Shokralla, H. A. and Fathalla, A. E. Granulosa Cell Tumors of the Ovary: Retrospective Analysis of 17 Cases. Journal of Cancer Therapy 2015; 6: 1027-1033.
[12]	Chadha S, Cornellisse CJ, Scha- berg A. Flow cytometric ploidy analysis of ovarian granulosa cell tumors. Gynecol Oncol 1990; 36: 240-5.
[13]	Lazrak, et al. Granulosa-cell tumor of the ovary. International Journal of Innovation and Applied Studies ISSN 2028-9324. 2014 Aug; 7 (3): 1020–1024. [Google Scholar].
[14]	Yi-Chan Chen L, Chang, Soong R. A late recurring and easily forgotten tumor: ovarian granulosa cell tumor. World Journal of Surgical Oncology. 2012; 79 (3): 776–4] [PubMed] [Google Scholar].
[15]	Schumer ST, Cannistra SA. Granulosa cell tumor of the ovary. J Clin Oncol 2003; 21: 1180-9.
[16]	Homesley HD, Bundy BN, Hurteau JA, Roth LM. Bleomycin, Etoposide, and Cisplatin combination therapy of ovarian granulosa cell tumors and other stromal malignancies: a gynecologic oncology group study. Gynecol Oncol 1999; 72: 131 7.
[17]	Briasoulis E, Karavasilis V, Pavlidis N. Megestrol activity in recurrent adult type granulosa cell tumour of the ovary. Ann Oncol 1997; 8: 811-2.

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APA Style

Zein Ahmed, Ahmedou Moulaye Idriss, Nacer Dine Ould Mohamed Baba, Isselmou Sidi. (2022). Tumor of the Granulosa of the Ovary About a Case. American Journal of Biomedical and Life Sciences, 10(3), 81-83. https://doi.org/10.11648/j.ajbls.20221003.14

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ACS Style

Zein Ahmed; Ahmedou Moulaye Idriss; Nacer Dine Ould Mohamed Baba; Isselmou Sidi. Tumor of the Granulosa of the Ovary About a Case. Am. J. Biomed. Life Sci. 2022, 10(3), 81-83. doi: 10.11648/j.ajbls.20221003.14

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AMA Style

Zein Ahmed, Ahmedou Moulaye Idriss, Nacer Dine Ould Mohamed Baba, Isselmou Sidi. Tumor of the Granulosa of the Ovary About a Case. Am J Biomed Life Sci. 2022;10(3):81-83. doi: 10.11648/j.ajbls.20221003.14

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@article{10.11648/j.ajbls.20221003.14,
  author = {Zein Ahmed and Ahmedou Moulaye Idriss and Nacer Dine Ould Mohamed Baba and Isselmou Sidi},
  title = {Tumor of the Granulosa of the Ovary About a Case},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {10},
  number = {3},
  pages = {81-83},
  doi = {10.11648/j.ajbls.20221003.14},
  url = {https://doi.org/10.11648/j.ajbls.20221003.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20221003.14},
  abstract = {Ovarian granulosa tumors are very rare; they belong to the group of sex cord and stromal tumors. Their slow evolution in the adult forms which are more frequent (95%) and less aggressive than the much rarer juvenile forms. The exact etiology of these tumors is unknown, but higher than normal estrogen levels are frequently found in women with ovarian granulosa cell tumors. A woman's menstrual status with excess estrogen is related to the presence of certain symptoms such as: early puberty in young women, increase in the size of the abdomen, menstrual cycle disorders in pre menopause or bleeding abnormal uteri in postmenopausal women. The most frequent ultrasound aspect is the solid-cystic aspect and pathological examination remains the diagnostic key. The treatment is essentially surgical, but sometimes associated with complementary therapies such as: chemotherapy, radiotherapy, hormone therapy. Recurrences occur late, hence the importance of post-therapeutic follow-up. Some aggressive forms relapse and progress more rapidly, which justifies rigorous therapeutic monitoring. The prognostic factors for recurrence identified in the literature are the FIGO stage, the presence of residual tumor and the tumor size. We report a case of observation and we draw attention to the epidemiological, clinical particularities, as well as the various prognostic factors in order to carry out a better therapeutic management.},
 year = {2022}
}

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TY  - JOUR
T1  - Tumor of the Granulosa of the Ovary About a Case
AU  - Zein Ahmed
AU  - Ahmedou Moulaye Idriss
AU  - Nacer Dine Ould Mohamed Baba
AU  - Isselmou Sidi
Y1  - 2022/06/27
PY  - 2022
N1  - https://doi.org/10.11648/j.ajbls.20221003.14
DO  - 10.11648/j.ajbls.20221003.14
T2  - American Journal of Biomedical and Life Sciences
JF  - American Journal of Biomedical and Life Sciences
JO  - American Journal of Biomedical and Life Sciences
SP  - 81
EP  - 83
PB  - Science Publishing Group
SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.20221003.14
AB  - Ovarian granulosa tumors are very rare; they belong to the group of sex cord and stromal tumors. Their slow evolution in the adult forms which are more frequent (95%) and less aggressive than the much rarer juvenile forms. The exact etiology of these tumors is unknown, but higher than normal estrogen levels are frequently found in women with ovarian granulosa cell tumors. A woman's menstrual status with excess estrogen is related to the presence of certain symptoms such as: early puberty in young women, increase in the size of the abdomen, menstrual cycle disorders in pre menopause or bleeding abnormal uteri in postmenopausal women. The most frequent ultrasound aspect is the solid-cystic aspect and pathological examination remains the diagnostic key. The treatment is essentially surgical, but sometimes associated with complementary therapies such as: chemotherapy, radiotherapy, hormone therapy. Recurrences occur late, hence the importance of post-therapeutic follow-up. Some aggressive forms relapse and progress more rapidly, which justifies rigorous therapeutic monitoring. The prognostic factors for recurrence identified in the literature are the FIGO stage, the presence of residual tumor and the tumor size. We report a case of observation and we draw attention to the epidemiological, clinical particularities, as well as the various prognostic factors in order to carry out a better therapeutic management.
VL  - 10
IS  - 3
ER  -

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Author Information

Zein Ahmed

Faculty of Médicine, Cheikh Zayed Hospital of Nouakchott, Nouakchott, Mauritania
Ahmedou Moulaye Idriss

Faculty of Médicine, National Hospital Center of Nouakchott, Nouakchott, Mauritania
Nacer Dine Ould Mohamed Baba

Faculty of Médicine, National Hospital Center of Nouakchott, Nouakchott, Mauritania
Isselmou Sidi

Faculty of Médicine, Cheikh Zayed Hospital of Nouakchott, Nouakchott, Mauritania

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APA Style

Zein Ahmed, Ahmedou Moulaye Idriss, Nacer Dine Ould Mohamed Baba, Isselmou Sidi. (2022). Tumor of the Granulosa of the Ovary About a Case. American Journal of Biomedical and Life Sciences, 10(3), 81-83. https://doi.org/10.11648/j.ajbls.20221003.14

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ACS Style

Zein Ahmed; Ahmedou Moulaye Idriss; Nacer Dine Ould Mohamed Baba; Isselmou Sidi. Tumor of the Granulosa of the Ovary About a Case. Am. J. Biomed. Life Sci. 2022, 10(3), 81-83. doi: 10.11648/j.ajbls.20221003.14

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AMA Style

Zein Ahmed, Ahmedou Moulaye Idriss, Nacer Dine Ould Mohamed Baba, Isselmou Sidi. Tumor of the Granulosa of the Ovary About a Case. Am J Biomed Life Sci. 2022;10(3):81-83. doi: 10.11648/j.ajbls.20221003.14

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@article{10.11648/j.ajbls.20221003.14,
  author = {Zein Ahmed and Ahmedou Moulaye Idriss and Nacer Dine Ould Mohamed Baba and Isselmou Sidi},
  title = {Tumor of the Granulosa of the Ovary About a Case},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {10},
  number = {3},
  pages = {81-83},
  doi = {10.11648/j.ajbls.20221003.14},
  url = {https://doi.org/10.11648/j.ajbls.20221003.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20221003.14},
  abstract = {Ovarian granulosa tumors are very rare; they belong to the group of sex cord and stromal tumors. Their slow evolution in the adult forms which are more frequent (95%) and less aggressive than the much rarer juvenile forms. The exact etiology of these tumors is unknown, but higher than normal estrogen levels are frequently found in women with ovarian granulosa cell tumors. A woman's menstrual status with excess estrogen is related to the presence of certain symptoms such as: early puberty in young women, increase in the size of the abdomen, menstrual cycle disorders in pre menopause or bleeding abnormal uteri in postmenopausal women. The most frequent ultrasound aspect is the solid-cystic aspect and pathological examination remains the diagnostic key. The treatment is essentially surgical, but sometimes associated with complementary therapies such as: chemotherapy, radiotherapy, hormone therapy. Recurrences occur late, hence the importance of post-therapeutic follow-up. Some aggressive forms relapse and progress more rapidly, which justifies rigorous therapeutic monitoring. The prognostic factors for recurrence identified in the literature are the FIGO stage, the presence of residual tumor and the tumor size. We report a case of observation and we draw attention to the epidemiological, clinical particularities, as well as the various prognostic factors in order to carry out a better therapeutic management.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - Tumor of the Granulosa of the Ovary About a Case
AU  - Zein Ahmed
AU  - Ahmedou Moulaye Idriss
AU  - Nacer Dine Ould Mohamed Baba
AU  - Isselmou Sidi
Y1  - 2022/06/27
PY  - 2022
N1  - https://doi.org/10.11648/j.ajbls.20221003.14
DO  - 10.11648/j.ajbls.20221003.14
T2  - American Journal of Biomedical and Life Sciences
JF  - American Journal of Biomedical and Life Sciences
JO  - American Journal of Biomedical and Life Sciences
SP  - 81
EP  - 83
PB  - Science Publishing Group
SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.20221003.14
AB  - Ovarian granulosa tumors are very rare; they belong to the group of sex cord and stromal tumors. Their slow evolution in the adult forms which are more frequent (95%) and less aggressive than the much rarer juvenile forms. The exact etiology of these tumors is unknown, but higher than normal estrogen levels are frequently found in women with ovarian granulosa cell tumors. A woman's menstrual status with excess estrogen is related to the presence of certain symptoms such as: early puberty in young women, increase in the size of the abdomen, menstrual cycle disorders in pre menopause or bleeding abnormal uteri in postmenopausal women. The most frequent ultrasound aspect is the solid-cystic aspect and pathological examination remains the diagnostic key. The treatment is essentially surgical, but sometimes associated with complementary therapies such as: chemotherapy, radiotherapy, hormone therapy. Recurrences occur late, hence the importance of post-therapeutic follow-up. Some aggressive forms relapse and progress more rapidly, which justifies rigorous therapeutic monitoring. The prognostic factors for recurrence identified in the literature are the FIGO stage, the presence of residual tumor and the tumor size. We report a case of observation and we draw attention to the epidemiological, clinical particularities, as well as the various prognostic factors in order to carry out a better therapeutic management.
VL  - 10
IS  - 3
ER  -

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