HIF-1α Related Signaling Pathway and Its Role in Common Gastrointestinal Tumors

Qing Wu; Yulei Xie; Yinxu Wang; Xin Chen

doi:doi:10.11648/j.ajbls.20221004.15

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HIF-1α Related Signaling Pathway and Its Role in Common Gastrointestinal Tumors

Qing Wu, Yulei Xie, Yinxu Wang, Xin Chen

Published in American Journal of Biomedical and Life Sciences (Volume 10, Issue 4)

Received: 16 February 2022 Accepted: 8 July 2022 Published: 5 August 2022

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Abstract

Esophageal cancer, gastric cancer and liver cancer are common digestive tract tumors. at present, radical surgery, radiotherapy and chemotherapy and traditional chinese medicine are the main clinical treatments for digestive tract tumors, but the morbidity and mortality of patients are still high. Therefore, it is very important to strengthen the research on the pathogenesis of digestive tract tumors. Therefore, it is very important to strengthen the research on the pathogenesis of digestive tract tumors in order to find the biomarkers and therapeutic targets for the early diagnosis of digestive tract tumors. Hypoxia-inducible factor-1 (Hypoxia-inducible factor-1, HIF-1), as an important regulator in hypoxia environment, is a heterodimer composed of subunits α and β. Its role is mainly determined by HIF-1α, by the fine regulation of O₂ content in the microenvironment, and participates in the regulation of a variety of tumor signal pathways. There is a strong correlation between high expression of HIF-1α and tumor metastasis, angiogenesis, poor prognosis and drug resistance treatment. This article reviews the research progress on the structure, function, expression regulation, action mechanism and role of HIF-1α in common digestive tract tumors, in order to provide theoretical basis for clinical treatment of digestive tract tumors.

Published in	American Journal of Biomedical and Life Sciences (Volume 10, Issue 4)
DOI	10.11648/j.ajbls.20221004.15
Page(s)	125-130
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Hypoxia Inducible Factor-1, Cell Signaling Pathway, Gastrointestinal Tumors

References

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APA Style

Qing Wu, Yulei Xie, Yinxu Wang, Xin Chen. (2022). HIF-1α Related Signaling Pathway and Its Role in Common Gastrointestinal Tumors. American Journal of Biomedical and Life Sciences, 10(4), 125-130. https://doi.org/10.11648/j.ajbls.20221004.15

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ACS Style

Qing Wu; Yulei Xie; Yinxu Wang; Xin Chen. HIF-1α Related Signaling Pathway and Its Role in Common Gastrointestinal Tumors. Am. J. Biomed. Life Sci. 2022, 10(4), 125-130. doi: 10.11648/j.ajbls.20221004.15

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AMA Style

Qing Wu, Yulei Xie, Yinxu Wang, Xin Chen. HIF-1α Related Signaling Pathway and Its Role in Common Gastrointestinal Tumors. Am J Biomed Life Sci. 2022;10(4):125-130. doi: 10.11648/j.ajbls.20221004.15

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@article{10.11648/j.ajbls.20221004.15,
  author = {Qing Wu and Yulei Xie and Yinxu Wang and Xin Chen},
  title = {HIF-1α Related Signaling Pathway and Its Role in Common Gastrointestinal Tumors},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {10},
  number = {4},
  pages = {125-130},
  doi = {10.11648/j.ajbls.20221004.15},
  url = {https://doi.org/10.11648/j.ajbls.20221004.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20221004.15},
  abstract = {Esophageal cancer, gastric cancer and liver cancer are common digestive tract tumors. at present, radical surgery, radiotherapy and chemotherapy and traditional chinese medicine are the main clinical treatments for digestive tract tumors, but the morbidity and mortality of patients are still high. Therefore, it is very important to strengthen the research on the pathogenesis of digestive tract tumors. Therefore, it is very important to strengthen the research on the pathogenesis of digestive tract tumors in order to find the biomarkers and therapeutic targets for the early diagnosis of digestive tract tumors. Hypoxia-inducible factor-1 (Hypoxia-inducible factor-1, HIF-1), as an important regulator in hypoxia environment, is a heterodimer composed of subunits α and β. Its role is mainly determined by HIF-1α, by the fine regulation of O2 content in the microenvironment, and participates in the regulation of a variety of tumor signal pathways. There is a strong correlation between high expression of HIF-1α and tumor metastasis, angiogenesis, poor prognosis and drug resistance treatment. This article reviews the research progress on the structure, function, expression regulation, action mechanism and role of HIF-1α in common digestive tract tumors, in order to provide theoretical basis for clinical treatment of digestive tract tumors.},
 year = {2022}
}

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TY  - JOUR
T1  - HIF-1α Related Signaling Pathway and Its Role in Common Gastrointestinal Tumors
AU  - Qing Wu
AU  - Yulei Xie
AU  - Yinxu Wang
AU  - Xin Chen
Y1  - 2022/08/05
PY  - 2022
N1  - https://doi.org/10.11648/j.ajbls.20221004.15
DO  - 10.11648/j.ajbls.20221004.15
T2  - American Journal of Biomedical and Life Sciences
JF  - American Journal of Biomedical and Life Sciences
JO  - American Journal of Biomedical and Life Sciences
SP  - 125
EP  - 130
PB  - Science Publishing Group
SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.20221004.15
AB  - Esophageal cancer, gastric cancer and liver cancer are common digestive tract tumors. at present, radical surgery, radiotherapy and chemotherapy and traditional chinese medicine are the main clinical treatments for digestive tract tumors, but the morbidity and mortality of patients are still high. Therefore, it is very important to strengthen the research on the pathogenesis of digestive tract tumors. Therefore, it is very important to strengthen the research on the pathogenesis of digestive tract tumors in order to find the biomarkers and therapeutic targets for the early diagnosis of digestive tract tumors. Hypoxia-inducible factor-1 (Hypoxia-inducible factor-1, HIF-1), as an important regulator in hypoxia environment, is a heterodimer composed of subunits α and β. Its role is mainly determined by HIF-1α, by the fine regulation of O2 content in the microenvironment, and participates in the regulation of a variety of tumor signal pathways. There is a strong correlation between high expression of HIF-1α and tumor metastasis, angiogenesis, poor prognosis and drug resistance treatment. This article reviews the research progress on the structure, function, expression regulation, action mechanism and role of HIF-1α in common digestive tract tumors, in order to provide theoretical basis for clinical treatment of digestive tract tumors.
VL  - 10
IS  - 4
ER  -

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Author Information

Qing Wu

Department of Rehabilitation Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
Yulei Xie

Department of Rehabilitation Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
Yinxu Wang

Department of Rehabilitation Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
Xin Chen

Department of Rehabilitation Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, China

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APA Style

Qing Wu, Yulei Xie, Yinxu Wang, Xin Chen. (2022). HIF-1α Related Signaling Pathway and Its Role in Common Gastrointestinal Tumors. American Journal of Biomedical and Life Sciences, 10(4), 125-130. https://doi.org/10.11648/j.ajbls.20221004.15

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ACS Style

Qing Wu; Yulei Xie; Yinxu Wang; Xin Chen. HIF-1α Related Signaling Pathway and Its Role in Common Gastrointestinal Tumors. Am. J. Biomed. Life Sci. 2022, 10(4), 125-130. doi: 10.11648/j.ajbls.20221004.15

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AMA Style

Qing Wu, Yulei Xie, Yinxu Wang, Xin Chen. HIF-1α Related Signaling Pathway and Its Role in Common Gastrointestinal Tumors. Am J Biomed Life Sci. 2022;10(4):125-130. doi: 10.11648/j.ajbls.20221004.15

Copy | Download

@article{10.11648/j.ajbls.20221004.15,
  author = {Qing Wu and Yulei Xie and Yinxu Wang and Xin Chen},
  title = {HIF-1α Related Signaling Pathway and Its Role in Common Gastrointestinal Tumors},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {10},
  number = {4},
  pages = {125-130},
  doi = {10.11648/j.ajbls.20221004.15},
  url = {https://doi.org/10.11648/j.ajbls.20221004.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20221004.15},
  abstract = {Esophageal cancer, gastric cancer and liver cancer are common digestive tract tumors. at present, radical surgery, radiotherapy and chemotherapy and traditional chinese medicine are the main clinical treatments for digestive tract tumors, but the morbidity and mortality of patients are still high. Therefore, it is very important to strengthen the research on the pathogenesis of digestive tract tumors. Therefore, it is very important to strengthen the research on the pathogenesis of digestive tract tumors in order to find the biomarkers and therapeutic targets for the early diagnosis of digestive tract tumors. Hypoxia-inducible factor-1 (Hypoxia-inducible factor-1, HIF-1), as an important regulator in hypoxia environment, is a heterodimer composed of subunits α and β. Its role is mainly determined by HIF-1α, by the fine regulation of O2 content in the microenvironment, and participates in the regulation of a variety of tumor signal pathways. There is a strong correlation between high expression of HIF-1α and tumor metastasis, angiogenesis, poor prognosis and drug resistance treatment. This article reviews the research progress on the structure, function, expression regulation, action mechanism and role of HIF-1α in common digestive tract tumors, in order to provide theoretical basis for clinical treatment of digestive tract tumors.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - HIF-1α Related Signaling Pathway and Its Role in Common Gastrointestinal Tumors
AU  - Qing Wu
AU  - Yulei Xie
AU  - Yinxu Wang
AU  - Xin Chen
Y1  - 2022/08/05
PY  - 2022
N1  - https://doi.org/10.11648/j.ajbls.20221004.15
DO  - 10.11648/j.ajbls.20221004.15
T2  - American Journal of Biomedical and Life Sciences
JF  - American Journal of Biomedical and Life Sciences
JO  - American Journal of Biomedical and Life Sciences
SP  - 125
EP  - 130
PB  - Science Publishing Group
SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.20221004.15
AB  - Esophageal cancer, gastric cancer and liver cancer are common digestive tract tumors. at present, radical surgery, radiotherapy and chemotherapy and traditional chinese medicine are the main clinical treatments for digestive tract tumors, but the morbidity and mortality of patients are still high. Therefore, it is very important to strengthen the research on the pathogenesis of digestive tract tumors. Therefore, it is very important to strengthen the research on the pathogenesis of digestive tract tumors in order to find the biomarkers and therapeutic targets for the early diagnosis of digestive tract tumors. Hypoxia-inducible factor-1 (Hypoxia-inducible factor-1, HIF-1), as an important regulator in hypoxia environment, is a heterodimer composed of subunits α and β. Its role is mainly determined by HIF-1α, by the fine regulation of O2 content in the microenvironment, and participates in the regulation of a variety of tumor signal pathways. There is a strong correlation between high expression of HIF-1α and tumor metastasis, angiogenesis, poor prognosis and drug resistance treatment. This article reviews the research progress on the structure, function, expression regulation, action mechanism and role of HIF-1α in common digestive tract tumors, in order to provide theoretical basis for clinical treatment of digestive tract tumors.
VL  - 10
IS  - 4
ER  -

Copy | Download