Low-level chronic exposure to heavy metals can go undetected for years accumulating in the human body which in turn can impact virtually any organ system. Lead is of particular concern given its prevalence, toxicological effects at low concentrations, and persistence in the body. In order to adequately regulate lead concentrations in food, water, air and consumer products, it is important to understand the relevant toxicodynamics and minimum risk levels at which deleterious effects are observed. An excellent resource is the lead toxicological profile published by the U.S. Center for Disease Control (CDC) Agency for Toxic Substances and Disease Registry (ATSDR) in cooperation with the U.S. Environmental Protection Agency (EPA). This peer-reviewed profile identifies and reviews published literature that describes human health effects, toxicokinetics, chemical and physical properties, and potential for human exposure. Since the release of that monograph in August of 2020, over 200 additional research papers have been published on the impact of lead exposure as it pertains to genotoxicity, cytotoxicity, neurological and cardiovascular effects to name a few. The purpose of this report is to review the published research since the release of the last ATSDR lead toxicology profile in order to present the most current studies relative to lead toxicodynamics, associated concentration levels, and potential areas for continuing research.
| Published in | American Journal of Biomedical and Life Sciences (Volume 10, Issue 5) |
| DOI | 10.11648/j.ajbls.20221005.12 |
| Page(s) | 135-145 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2022. Published by Science Publishing Group |
Lead, Heavy Metals, Toxicity, Toxicodynamics, Review
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APA Style
Prince Sellase Gameli, Grant Fleming, Marjanii Walton, Tom Gluodenis. (2022). Human Health Effects from Exposure to Lead: A Review of the Current Literature. American Journal of Biomedical and Life Sciences, 10(5), 135-145. https://doi.org/10.11648/j.ajbls.20221005.12
ACS Style
Prince Sellase Gameli; Grant Fleming; Marjanii Walton; Tom Gluodenis. Human Health Effects from Exposure to Lead: A Review of the Current Literature. Am. J. Biomed. Life Sci. 2022, 10(5), 135-145. doi: 10.11648/j.ajbls.20221005.12
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Download@article{10.11648/j.ajbls.20221005.12,
author = {Prince Sellase Gameli and Grant Fleming and Marjanii Walton and Tom Gluodenis},
title = {Human Health Effects from Exposure to Lead: A Review of the Current Literature},
journal = {American Journal of Biomedical and Life Sciences},
volume = {10},
number = {5},
pages = {135-145},
doi = {10.11648/j.ajbls.20221005.12},
url = {https://doi.org/10.11648/j.ajbls.20221005.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20221005.12},
abstract = {Low-level chronic exposure to heavy metals can go undetected for years accumulating in the human body which in turn can impact virtually any organ system. Lead is of particular concern given its prevalence, toxicological effects at low concentrations, and persistence in the body. In order to adequately regulate lead concentrations in food, water, air and consumer products, it is important to understand the relevant toxicodynamics and minimum risk levels at which deleterious effects are observed. An excellent resource is the lead toxicological profile published by the U.S. Center for Disease Control (CDC) Agency for Toxic Substances and Disease Registry (ATSDR) in cooperation with the U.S. Environmental Protection Agency (EPA). This peer-reviewed profile identifies and reviews published literature that describes human health effects, toxicokinetics, chemical and physical properties, and potential for human exposure. Since the release of that monograph in August of 2020, over 200 additional research papers have been published on the impact of lead exposure as it pertains to genotoxicity, cytotoxicity, neurological and cardiovascular effects to name a few. The purpose of this report is to review the published research since the release of the last ATSDR lead toxicology profile in order to present the most current studies relative to lead toxicodynamics, associated concentration levels, and potential areas for continuing research.},
year = {2022}
}
TY - JOUR T1 - Human Health Effects from Exposure to Lead: A Review of the Current Literature AU - Prince Sellase Gameli AU - Grant Fleming AU - Marjanii Walton AU - Tom Gluodenis Y1 - 2022/10/11 PY - 2022 N1 - https://doi.org/10.11648/j.ajbls.20221005.12 DO - 10.11648/j.ajbls.20221005.12 T2 - American Journal of Biomedical and Life Sciences JF - American Journal of Biomedical and Life Sciences JO - American Journal of Biomedical and Life Sciences SP - 135 EP - 145 PB - Science Publishing Group SN - 2330-880X UR - https://doi.org/10.11648/j.ajbls.20221005.12 AB - Low-level chronic exposure to heavy metals can go undetected for years accumulating in the human body which in turn can impact virtually any organ system. Lead is of particular concern given its prevalence, toxicological effects at low concentrations, and persistence in the body. In order to adequately regulate lead concentrations in food, water, air and consumer products, it is important to understand the relevant toxicodynamics and minimum risk levels at which deleterious effects are observed. An excellent resource is the lead toxicological profile published by the U.S. Center for Disease Control (CDC) Agency for Toxic Substances and Disease Registry (ATSDR) in cooperation with the U.S. Environmental Protection Agency (EPA). This peer-reviewed profile identifies and reviews published literature that describes human health effects, toxicokinetics, chemical and physical properties, and potential for human exposure. Since the release of that monograph in August of 2020, over 200 additional research papers have been published on the impact of lead exposure as it pertains to genotoxicity, cytotoxicity, neurological and cardiovascular effects to name a few. The purpose of this report is to review the published research since the release of the last ATSDR lead toxicology profile in order to present the most current studies relative to lead toxicodynamics, associated concentration levels, and potential areas for continuing research. VL - 10 IS - 5 ER -
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