A certain number of fMRI studies on subjective cognitive decline (SCD) have been widely debated. They mainly focus on the differences in brain structure and function between SCD and normal people, while more studies focus on objective cognitive decline. The relationship between psychological factors and SCD via cerebral fMRI data in the elderly is rarely discussed. In this study, we included 66 SCD patients and 63 normal controls (NC) to investigate the neural processes amid the psychological aspects of those with subclinical depression and SCD using dynamic network connectivity and to provide theoretical support for neuroimaging for improved Alzheimer's disease prevention and therapy. We calculated temporal flexibility and spatiotemporal diversity via fMRI data using Shen’s 268 brain template and No. 74 brain region was selected by t-test and correlation analysis. In the NC group, no significant correlation was observed in temporal flexibility value of No. 74–SCD and Hamilton depression scale HAMD–SCD, whereas No. 74–HAMD showed a significant correlation. In the SCD group, all of the three parameters exhibited significant correlation. Mediation analysis obtained the mediation model of No. 74 brain region, subclinical depression, and subjective cognitive decline (No. 74→HAMD→SCD). The results show that visual system plays an important role in subclinical depression, and subclinical depression increases the risk of SCD.
| Published in | American Journal of Biomedical and Life Sciences (Volume 10, Issue 6) |
| DOI | 10.11648/j.ajbls.20221006.12 |
| Page(s) | 162-167 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2022. Published by Science Publishing Group |
Subjective Cognitive Decline, Subclinical Depression, Dynamic Network Connectivity, Temporal Flexibility, fMRI
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APA Style
Zhao Zhang, Guangfei Li, Zeyu Song, Xiaoying Tang. (2022). A Study of Subjective Cognitive Decline and Subclinical Depression Based on Dynamic Network Connectivity of Cerebral fMRI Data. American Journal of Biomedical and Life Sciences, 10(6), 162-167. https://doi.org/10.11648/j.ajbls.20221006.12
ACS Style
Zhao Zhang; Guangfei Li; Zeyu Song; Xiaoying Tang. A Study of Subjective Cognitive Decline and Subclinical Depression Based on Dynamic Network Connectivity of Cerebral fMRI Data. Am. J. Biomed. Life Sci. 2022, 10(6), 162-167. doi: 10.11648/j.ajbls.20221006.12
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Download@article{10.11648/j.ajbls.20221006.12,
author = {Zhao Zhang and Guangfei Li and Zeyu Song and Xiaoying Tang},
title = {A Study of Subjective Cognitive Decline and Subclinical Depression Based on Dynamic Network Connectivity of Cerebral fMRI Data},
journal = {American Journal of Biomedical and Life Sciences},
volume = {10},
number = {6},
pages = {162-167},
doi = {10.11648/j.ajbls.20221006.12},
url = {https://doi.org/10.11648/j.ajbls.20221006.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20221006.12},
abstract = {A certain number of fMRI studies on subjective cognitive decline (SCD) have been widely debated. They mainly focus on the differences in brain structure and function between SCD and normal people, while more studies focus on objective cognitive decline. The relationship between psychological factors and SCD via cerebral fMRI data in the elderly is rarely discussed. In this study, we included 66 SCD patients and 63 normal controls (NC) to investigate the neural processes amid the psychological aspects of those with subclinical depression and SCD using dynamic network connectivity and to provide theoretical support for neuroimaging for improved Alzheimer's disease prevention and therapy. We calculated temporal flexibility and spatiotemporal diversity via fMRI data using Shen’s 268 brain template and No. 74 brain region was selected by t-test and correlation analysis. In the NC group, no significant correlation was observed in temporal flexibility value of No. 74–SCD and Hamilton depression scale HAMD–SCD, whereas No. 74–HAMD showed a significant correlation. In the SCD group, all of the three parameters exhibited significant correlation. Mediation analysis obtained the mediation model of No. 74 brain region, subclinical depression, and subjective cognitive decline (No. 74→HAMD→SCD). The results show that visual system plays an important role in subclinical depression, and subclinical depression increases the risk of SCD.},
year = {2022}
}
TY - JOUR T1 - A Study of Subjective Cognitive Decline and Subclinical Depression Based on Dynamic Network Connectivity of Cerebral fMRI Data AU - Zhao Zhang AU - Guangfei Li AU - Zeyu Song AU - Xiaoying Tang Y1 - 2022/12/08 PY - 2022 N1 - https://doi.org/10.11648/j.ajbls.20221006.12 DO - 10.11648/j.ajbls.20221006.12 T2 - American Journal of Biomedical and Life Sciences JF - American Journal of Biomedical and Life Sciences JO - American Journal of Biomedical and Life Sciences SP - 162 EP - 167 PB - Science Publishing Group SN - 2330-880X UR - https://doi.org/10.11648/j.ajbls.20221006.12 AB - A certain number of fMRI studies on subjective cognitive decline (SCD) have been widely debated. They mainly focus on the differences in brain structure and function between SCD and normal people, while more studies focus on objective cognitive decline. The relationship between psychological factors and SCD via cerebral fMRI data in the elderly is rarely discussed. In this study, we included 66 SCD patients and 63 normal controls (NC) to investigate the neural processes amid the psychological aspects of those with subclinical depression and SCD using dynamic network connectivity and to provide theoretical support for neuroimaging for improved Alzheimer's disease prevention and therapy. We calculated temporal flexibility and spatiotemporal diversity via fMRI data using Shen’s 268 brain template and No. 74 brain region was selected by t-test and correlation analysis. In the NC group, no significant correlation was observed in temporal flexibility value of No. 74–SCD and Hamilton depression scale HAMD–SCD, whereas No. 74–HAMD showed a significant correlation. In the SCD group, all of the three parameters exhibited significant correlation. Mediation analysis obtained the mediation model of No. 74 brain region, subclinical depression, and subjective cognitive decline (No. 74→HAMD→SCD). The results show that visual system plays an important role in subclinical depression, and subclinical depression increases the risk of SCD. VL - 10 IS - 6 ER -
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