Pathophysiological Effects of Alcohol and Tobacco Consumption on Semen Parameters of Men Attending a Fertility Clinic in West Africa

Philip Vatcanarat Baysah; Aloysius Obinna Ikwuka; Francis Chigozie Udeh; Darius Popo Bleh; Thamara Viloria

doi:doi:10.11648/j.ajbls.20231104.13

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Pathophysiological Effects of Alcohol and Tobacco Consumption on Semen Parameters of Men Attending a Fertility Clinic in West Africa

Philip Vatcanarat Baysah, Aloysius Obinna Ikwuka, Francis Chigozie Udeh, Darius Popo Bleh, Thamara Viloria

Published in American Journal of Biomedical and Life Sciences (Volume 11, Issue 4)

Received: 12 July 2023 Accepted: 28 July 2023 Published: 5 August 2023

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Abstract

Background: Alcohol and tobacco consumption are prevalent global habits. There is existing evidence linking these habits to male infertility, although the impact they have on male fertility and reproductive outcomes are yet to be exhaustively investigated. Aim: This study aimed to study the pathophysiological effects of alcohol and tobacco consumption on semen parameters of men attending a fertility clinic in West Africa. Materials and Methods: Semen samples were collected from 196 men who attend Medlink Clinic, Monrovia, Liberia and parameters including sperm volume, count, motility, and morphology were evaluated according to the WHO criteria. The Chi-square test (χ²) of the SPSS version 23 statistical software was used to test for hypotheses at a significance level of p<0.05. Results: The mean age of the men was 37.8±10.3 years. 20.9% of the study participants abstain from alcohol and tobacco, 38.8% consume alcohol, and 40.3% consume tobacco. Among the study participants, 36 (18.4%) had normospermia, 74 (37.8%) had oligospermia, 8 (4.1%) had cryptozoospermia, 5 (2.6%) had azoospermia, 58 (29.6%) had asthenozoospermia, and 15 (7.7%) had teratozoospermia. However, 78.9% frequent alcohol consumers, 47.4% non-frequent alcohol consumers, 77.8% non-alcohol consumers, 89.8% tobacco smokers, and 69.6% non-tobacco smokers had poor semen quality. The hypotheses tested proved that there is a significant relationship (p=0.024) between alcohol/tobacco consumption and poor semen quality, whereas there is no significant relationship (p=0.56) between non-consumption of alcohol/tobacco and good semen quality. There is also a significant relationship (p=0.0086) between alcohol consumption only and poor semen quality. Conclusion: Alcohol and tobacco consumption reduce male sperm quality, but abstinence from both does not guarantee optimum semen quality. Alcohol and/or tobacco consumption adversely affect the semen parameters (sperm volume, count, motility, and morphology).

Published in	American Journal of Biomedical and Life Sciences (Volume 11, Issue 4)
DOI	10.11648/j.ajbls.20231104.13
Page(s)	73-81
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2023. Published by Science Publishing Group

Keywords

Pathophysiology, Tobacco, Alcohol Consumption, Semen Parameters, Semen Quality, Male Fertility

References

[1]	Abdullah AA, Ahmed M, Oladokun A. Prevalence of infertility in Sudan: A systematic review and meta-analysis. Qatar Medical Journal. 2021; 2021 (3): 47-57.
[2]	Afeiche M, Williams PL, Mendiola J, Gaskins AJ, Jørgensen N, Swan SH, et al. Dairy food intake in relation to semen quality and reproductive hormone levels among physically active young men. Human Reproduction. 2013; 28 (8): 2265–2275.
[3]	Ali AFM, Modawe G, Rida MA, Abdrabo AA. Prevalence of abnormal semen parameters among male patients attending the fertility center in Khartoum, Sudan. Journal of Medical and Life Science. 2022; 4 (1): 1-8.
[4]	Amor H, Hammadeh ME, Mohd I, Jankowski PM. Impact of heavy alcohol consumption and cigarette smoking on sperm DNA integrity. Andrologia. 2022; 54 (7): e14434.
[5]	Amor H, Zeyad A, Hammadeh ME. Tobacco smoking and its impact on the expression level of sperm nuclear protein genes: H2BFWT, TNP1, TNP2, PRM1 and PRM2. Andrologia. 2021; 53: e13964. DOI: 10.1111/and.13964.
[6]	Barazani Y, Katz BF, Nagler HM, Stember DS. Lifestyle, environment, and male reproductive health. Urologic Clinics of North America. 2014; 41 (1): 55–66.
[7]	Boeri L, Capogrosso P, Ventimiglia E, Pederzoli F, Cazzaniga W, Chierigo F, et al. Heavy cigarette smoking and alcohol consumption are associated with impaired sperm parameters in primary infertile men. Asian Journal of Andrology. 2019; 21 (5): 478–485. DOI: 10.4103/aja.aja_110_18.
[8]	Center for Disease Control and Prevention. General alcohol information. Fact Sheet. Atlanta, GA: CDC, 2005. Available online: www.cdc.gov/alcohol/factsheets/general_information.htm
[9]	Center for Disease Control and Prevention. The health consequences of smoking: A report of the surgeon general. Atlanta, GA: U.S. Department of Health and Human Services, CDC, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2004.
[10]	Clemens KJ, Caillé S, Stinus L, Cador M. The addition of five minor tobacco alkaloids increases nicotine-induced hyperactivity, sensitization and intravenous self-administration in rats. International Journal of Neuropsychopharmacology. 2009; 12 (10): 1355-1366.
[11]	Condorelli RA, Calogero AE, Vicari E, La Vignera S. Chronic consumption of alcohol and sperm parameters: our experience and the main evidences. Andrologia. 2015; 47 (4): 368–379. DOI: 10.1111/and.12284.
[12]	Conklin KA. Dietary antioxidants during cancer chemotherapy: impact on chemotherapeutic effectiveness and development of side effects. Nutrition and Cancer. 2000; 37 (1): 1-18. DOI: 10.1207/S15327914NC3701_1.
[13]	Cui X, Jing X, Wu X, Wang Z, Li Q. Potential effect of smoking on semen quality through DNA damage and the downregulation of Chk1 in sperm. Molecular Medicine Reports. 2016; 14 (1): 753–761. DOI: 10.3892/MMR.2016.5318/HTML.
[14]	Doshi SB, Khullar K, Sharma RK, Agarwal A. Role of reactive nitrogen species in male infertility. Reproductive Biology and Endocrinology. 2012; 10: 1–11.
[15]	Ekechi HO, Ikwuka AO, Udeh FC, Abraham JC. Effects of ethanol extract of Rauwolfiavomitorialeaf on lipid profile and cerebellar histology in cisplatin-induced oxidative stress. British Journal of Medical and Health Research. 2023; 10 (5): 16-39. DOI: 10.5281/zenodo.8042521.
[16]	Fang YY, Wu QJ, Zhang TN, Wang TR, Shen ZQ, Jiao J, et al. Assessment of the development of assisted reproductive technology in Liaoning province of China, from 2012 to 2016. BMC Health Services Research. 2018; 18 (1): 873. DOI: 10.1186/s12913-018-35.
[17]	Halmenschlager G, Rossetto S, Lara GM, Rhoden EL. Evaluation of the effects of cigarette smoking on testosterone levels in adult men. Journal of Sexual Medicine. 2009; 6 (6): 1763–1772. DOI: 10.1111/j.1743-6109.2009.01227.x.
[18]	Hamad MF, Shelko N, Kartarius S, Montenarh M, HammadehME. Impact of cigarette smoking on histone (H2B) to protamine ratio in human spermatozoa and its relation to sperm parameters. Andrology. 2014; 2: 666–677. DOI: 10.1111/j.2047-2927.2014.00245.x.
[19]	Hansen ML, Thulstrup AM, Bonde JP, Olsen J, Hakonsen LB, RamlauHansen CH. Does last week’s alcohol intake affect semen quality or reproductive hormones? A cross-sectional study among healthy young Danish men. Reproductive Toxicology. 2012; 34: 457–462.
[20]	Heishman SJ, Kozlowski LT, Henningfield JE. Nicotine addiction: Implication for public health policy. Journal of Social Issues. 2010; 53 (1): 13-33.
[21]	Ikwuka AO. Risk factors for the pathogenesis of diabetes mellitus type 2. Materials of 84th Scientific and Practical Conference of Students and Young Scientists with International Participation “Innovations in medicine”. 2015; p. 19. Available online: http://www.ifnmu.edu.ua/images/snt/files/konferenciya/Tezu_2015.pdf
[22]	Ikwuka AO. Dyslipidemia risk severity in patients with diabetes mellitus type 2 and essential hypertension. Journal of the 21st International Medical Congress of Students and Young Scientists. 2017; p. 59.
[23]	Ikwuka AO. Effectiveness of dapagliflozin in patients with diabetes mellitus type 2 and essential hypertension. Book of abstracts of the 7th International Students’ Scientific Conference of Young Medical Researchers. 2017; p. 102. Available online: http://www.stn.umed.wroc.pl/files/lm/Accepted_papers.16113.pdf
[24]	Ikwuka AO. Influence of dyslipidemia in patients with diabetes mellitus type 2 and essential hypertension. The Pharma Innovation Journal. 2017; 6 (3): 101-103. Available online: http://www.thepharmajournal.com/archives/?year=2017&vol=6&issue=3&part=B
[25]	Ikwuka AO, Haman IO. Features of kidney damage in patients with diabetes mellitus type 2 and essential hypertension. Journal of 86th Scientific and Practical Conference of Students and Young Scientists with International Participation “Innovations in medicine”. 2017; p. 144. Available online: http://www.ifnmu.edu.ua/images/snt/86-konf-tezi%20(1).pdf
[26]	Ikwuka AO, Virstyuk NG, Luchko OR. Features of the functional state of kidneys in patients with diabetes mellitus type 2 and essential arterial hypertension. Materials of scientific-practical conference with international participation “Babenkivski reading”. 2017; p. 48.
[27]	Ikwuka AO. Clinical dynamics in patients with diabetes mellitus type 2 and concomitant essential hypertensive disease treated with dapagliflozin. Journal of the 22nd International Medical Congress of Students and Young Scientists. 2018; p. 32.
[28]	Ikwuka AO. Clinical effectiveness of SGLT-2 inhibitors in patients with diabetes mellitus type 2 and essential hypertensive disease. Endocrine Practice. 2018; 24 (1): 74. DOI: 10.1016/S1530-891X(20)47129-0.
[29]	Ikwuka AO. Features of kidney damage in patients with arterial hypertension and type 2 diabetes mellitus and optimization of treatment. Specialized Academic Council IFNMU. 2018; Available online: http://www.ifnmu.edu.ua/images/zagalna_informacia/spec_vcheni_radi/2017-2019/%D0%9420.601.01/Ikvuka/Avtoreferat.pdf
[30]	Ikwuka AO, Paliy Yu. Structural changes of the left ventricular myocardium in patients with essential arterial hypertension and diabetes mellitus type 2. Abstracts of the 87th Scientific Conference of Students and Young Scientists with International Participation “Innovations in medicine”. 2018; p. 25-26. Available online: https://www.ifnmu.edu.ua/images/snt/zaproshennia_eng.pdf
[31]	Ikwuka AO. Clinical dynamics of nephropathy in patients with diabetes mellitus type 2 and concomitant essential hypertensive disease. Clinical Medicine. 2019; 19 (2): s39. DOI: 10.7861/clinmedicine.19-2-s39.
[32]	Ikwuka AO. Clinical effectiveness of GLP-1 RAs in patients with metabolic syndrome diseases. Endocrine Practice. 2019; 25 (1): 104-105. DOI: 10.1016/S1530-891X(20)46611-X.
[33]	Ikwuka AO. Dr. Aloy's Core Essential Series (DACES) Immunology. 1st Edition. Science and Education Publishing, USA. 2023; p. 31. ISBN: 978-978-795-866-7.
[34]	Ikwuka AO. Dr. Aloy's Core Essential Series (DACES) Medical Genetics. 1st Edition. Science and Education Publishing, USA. 2023; p. 9. ISBN: 978-1-958293-02-7.
[35]	Ikwuka AO, Virstyuk NG. Pattern of cardiac remodelling of the left ventricle in patients with essential hypertensive disease and concomitant type 2 diabetes mellitus. Clinical Medicine. 2019; 19 (3): s92. DOI: 10.7861/clinmedicine.19-3-s92.
[36]	Ikwuka AO, Virstyuk NG. Influence of SGLT2 inhibitor and A2RB (AT1) on fibrogenesis and heart failure in patients with essential hypertensive disease combined with diabetes mellitus type 2. E-Poster No. 143 of the 44th & 45th Annual General and Scientific Meeting of the West African College of Physicians (WACP), 1 - 3 November, 2021. 2021; DOI: 10.13140/RG.2.2.26912.87047.
[37]	Ikwuka AO, Virstyuk N. Prognostic markers of nephropathy in patients with dual metabolic syndrome diseases (essential hypertensive disease and concomitant type 2 diabetes mellitus). Endocrine Practice. 2022; 28 (5): S65-S66. DOI: 10.1016/j.eprac.2022.03.164.
[38]	Ikwuka AO, Virstyuk N. Patterns and Influence of Cardio-Metabolic Insufficiency in Patients with Essential Hypertensive Disease and Concomitant Type 2 Diabetes Mellitus. Endocrine Practice. 2023; 29 (5): S32-S33. DOI: 10.1016/j.eprac.2023.03.076.
[39]	Ikwuka AO, Virstyuk NG, Luchko OR, Kobitovych I. Heterogeneity Of Renal Pathogenicity On The Background Of Asymptomatic Hyperuricemia In Patients With Dual Metabolic Syndrome Diseases (Essential Hypertensive Disease and Type 2 Diabetes Mellitus). British Journal of Medical and Health Research. 2023; 10 (2): 1-9. DOI: 10.5281/zenodo.7690636.
[40]	International Agency for Research on Cancer Working Group. Smokeless tobacco and some tobacco-specific N-nitrosamines. World Health Organization Monographs on the Evaluation of Carcinogenic Risks to Humans. 2007; 89: 345-346.
[41]	Irvine DS. Epidemiology and aetiology of male infertility. Human Reproduction. 1998; 13 (1): 33–44.
[42]	Jajoo S, Kalyani KR. Prevalence of abnormal semen analysis in patients of infertility at a rural set up in central India. International Journal of Reproduction, Contraception, Obstetrics, and Gynecology. 2013; 2: 161-164.
[43]	Jorsaraei SGA, Shibahara H, Ayustawati HY, Shiraishi Y, Khalatbari A, Pasha YY, et al. The in-vitro effects of nicotine, cotinine and leptin on sperm parameters analyzed by CASA system. Iranian Journal of Reproductive Medicine. 2008; 6 (3): 157–165.
[44]	Kalavathi DB. Male factor in infertility: Study from a tertiary care hospital. International Journal of Reproduction, Contraception, Obstetrics, and Gynecology. 2016; 5 (6): 2022-2025.
[45]	Kamal K. Monograph of tobacco (Nicotianatabacum). Indian Journal of Drugs. 2014; 2 (1): 5-23.
[46]	Kumar SB, Chawla B, Bisht S, Yadav RK, Dada R. Tobacco use increases oxidative DNA damage in sperm - possible etiology of childhood cancer. Asian Pacific Journal of Cancer Prevention. 2015; 16: 6967–6972. DOI: 10.7314/APJCP.2015.16.16.6967.
[47]	La Maestra S, De Flora S, Micale RT. Effect of cigarette smoke on DNA damage, oxidative stress, and morphological alterations in mouse testis and spermatozoa. International Journal of Hygiene and Environmental Health. 2015; 218: 117–122.
[48]	Majo J, Ghezzo H, Cosio MG. Lymphocyte population and apoptosis in the lungs of smokers and their relation to emphysema. European Respiratory Journal. 2001; 17 (5): 946–953. DOI: 10.1183/09031936.01.17509460.
[49]	Mostafa T. Cigarette smoking and male infertility. Journal of Advanced Research. 2010; 1 (3): 179–186. DOI: 10.1016/J.JARE. 2010.05.002.
[50]	Muthusami KR, Chinnaswamy P. Effect of chronic alcoholism on male fertility hormones and semen quality. Fertility and Sterility. 2005; 84: 919–924. DOI: 10.1016/j.fertnstert.2005.04.025.
[51]	Pant N, Kumar G, Upadhyay AD, Patel DK, Gupta YK, Chaturvedi PK. Reproductive toxicity of lead, cadmium, and phthalate exposure in men. Environmental Science and Pollution Research. 2014; 21 (18): 11066–11074. DOI: 10.1007/s11356- 014-2986-5.
[52]	Raj A, Iqbal B, Sharma A, Gore CR, Kumar H, Singh M. Effect of alcohol and smoking on semen analysis parameters. Medical Journal of Dr. D. Y. PatilVidyapeeth. 2022; 15 (5): 696-700.
[53]	Ramya C, Renuka IV, Premalatha P, Madhavi K. Patterns of semen analysis in male partners of infertile couples at a tertiary care hospital. Indian Journal of Pathology and Oncology. 2017; 4 (4): 536-539.
[54]	Ricci E, Noli S, Ferrari S, La Vecchia I, Cipriani S, De Cosmi V, et al. Alcohol intake and semen variables: cross-sectional analysis of a prospective cohort study of men referring to an Italian Fertility Clinic. Andrology. 2018; 6 (5): 690-696.
[55]	Sadler TW. Langman’s Medical Embryology. 12th Edition. Lippincott Williams & Wilkin. 2012; p. 36-42.
[56]	Saha S, Roy P, Corbitt C, Kakar SS. Application of stem cell therapy for infertility. Cells. 2021; 10: 1613. DOI: 10.3390/ cells10071613.
[57]	Saleh RA, Agarwal A, Sharma RK, Said TM, Sikka SC, Thomas AJ. Evaluation of nuclear DNA damage in spermatozoa from infertile men with varicocele. Fertility and Sterility. 2003; 80 (6): 1431–1436. DOI: 10.1016/S0015-0282(03)02211-8.
[58]	Samal S, Dhadwe K, Gupta U, Gupta NK. Epidemiological study of male infertility. Indian Medical Gazette. 2012; 6 (5): 174-180.
[59]	Sengupta P, Dutta S, Krajewska-Kulak E. The disappearing sperms: Analysis of reports published between 1980 and 2015. American Journal of Men's Health. 2017; 11 (4): 1279–1304. DOI: 10.1177/1557988316643383.
[60]	The World Bank. Data: Prevalence of current tobacco use, males (% of male adults)-Liberia. 2023. Available online: https://data.worldbank.org/indicator/SH.PRV.SMOK.MA?locations=LR
[61]	The World Bank. Data: Total alcohol consumption per capita (liters of pure alcohol, projected estimates, 15+ years of age) - Liberia. 2023. Available online: https://data.worldbank.org/indicator/SH.ALC.PCAP.LI?locations=LR
[62]	Tsermpini EE, PlemenitašIlješ A, Dolžan V. Alcohol-induced oxidative stress and the role of antioxidants in alcohol use disorder: A systematic review. Antioxidants. 2022; 11: 1374-1407. DOI: 10.3390/ antiox11071374.
[63]	Udeh FC, Ikwuka AO, Epete MA, Igwe EC. Effects of local tobacco snuff ingestion during pregnancy on renal functions and histology architecture of female Wistar rats and on the birth weight of their pups. American Journal of Medical Sciences and Medicine. 2023; 11 (1): 1-5. DOI: 10.12691/ajmsm-11-1-1.
[64]	Udeh FC, Ikwuka AO, Epete MA, Igwe EC. Effects of oral consumption of Nicotianatabacumduring pregnancy on the liver and prolactin levels of adult female Wistar rats. European Journal of Veterinary Medicine. 2023; 3 (2): 1-5. DOI: 10.24018/ejvetmed.2023.3.2.93.
[65]	Virstyuk NG, Ikwuka AO, Haman IO, Adebomi MS. Diabetes mellitus type 2, arterial hypertension and dyslipidemia. Materials of 2nd International Scientific and Practical Conference "Therapeutic readings: modern aspects of diagnosis and treatment of diseases of internal organs". 2016; p. 46-47.
[66]	Virstyuk NG, Ikwuka AO. Diagnostic and prognostic markers of the diabetes mellitus type 2 course in connection with essential arterial hypertension taking into account the kidney function. Precarpathian Journal Pulse (ISSN: 2304-7437). 2017; 8 (44): 53-62.
[67]	Virstyuk NG, Ikwuka AO. Features of asymptomatic hyperuricemia in patients with diabetes mellitus type 2 and concomitant essential arterial hypertension. Clinical and Experimental Pathology. 2018; 1 (63): 22-26. DOI: 10.24061/1727-4338.XVII.1.63.2018.5.
[68]	Virstyuk NG, Ikwuka AO. Nephropathic characteristics in patients with diabetes mellitus type 2 and essential hypertensive disease. Art of Medicine. 2019; 1 (5): 44-47. DOI: 10.21802/artm.2019.1.9.44.
[69]	Virstyuk NG, Ikwuka AO. Asymptomatic hyperuricemia and functional state of the kidneys in patients with essential arterial hypertension and concomitant diabetes mellitus type 2. European Journal of Clinical Medicine. 2021; 2 (3): 100-104. DOI: 10.24018/clinicmed.2021.2.3.65.
[70]	Virstyuk NG, Ikwuka AO, Didushko OM. Effect of dapagliflozin on the level of uric acid during asymptomatic hyperuricemia in patients with diabetes mellitus type 2 and concomitant arterial hypertension. Art of Medicine. 2018; 1 (5): 21-26. Available online: https://art-of-medicine.ifnmu.edu.ua/index.php/aom/article/view/179/150
[71]	Virstyuk NH, Ikwuka AO. Dapagliflozin influence on the clinical course of diabetes mellitus type 2 and essential hypertension in patients. Recent Advances in Environmental Science from the Euro-Mediterranean and Surrounding Regions. Springer International Publishing AG. 2018; p. 2007-2008. DOI: 10.1007/978-3-319-70548-4_582.
[72]	Virstyuk NH, Ikwuka AO, Losyuk LV, Kobrynska OYa, Markiv HD. Dapagliflozin utility in patients with diabetes mellitus type 2 and essential hypertensive disease. Actual Problems of Modern Medicine. 2017; 4 (60) 1: 76-79. Available online: http://www.umsa.edu.ua/journal2stat4_2017_eng.html
[73]	Virstyuk NH, Ikwuka AO, Luchko OR, Kocherzhat OI. Peculiarities of renal insufficiency in patients with diabetes mellitus type 2 and arterial hypertension. Materials of scientific-practical conference with international participation "Achievements and prospects of experimental and clinical endocrinology" Twentieth Danilevsky readings. 2021; p. 86-87.
[74]	World Health Organization. Fertility. 2020; Available online: https://www.who.int/news-room/fact-sheets/detail/infertility
[75]	World Health Organization. Standard Procedures. In: Cooper TG, editor. WHO Laboratory Manual for the Examination and Processing of Human Semen. 5th ed. Geneva. World Health Organization. 2010; p. 1 141.
[76]	World Health Organization. The World Health Observatory. 2023; Available online: https://www.who.int/data/gho/data/themes/global-information-system-on-alcohol-and-health
[77]	World Health Organization. Tobacco. Fact Sheets. 2022; Available online: https://www.who.int/news-room/fact-sheets/detail/tobacco
[78]	Wright J, Duchesne C, Sabourin S, Bissonnette F, Benoit J, Girard Y. Psychosocial distress and infertility: men and women respond differently in vitro. Fertility and Sterility. 1991; 55: 100-108.
[79]	Wu D, Cederbaum AI. Alcohol, oxidative stress, and free radical damage. Alcohol Research and Health. 2003; 27 (4): 277– 284. DOI: 10.1079/pns2006496.
[80]	Zegers Hochschild F, Adamson GD, de Mouzon J, Ishihara O, Mansour R, Nygren K, et al. The International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) revised glossary on ART terminology, 2009. Human Reproduction. 2009; 24: 2683 2687.
[81]	Zorn B, Vidmar G, Meden-Vrtovec H. Seminal reactive oxygen species as predictors of fertilization, embryo quality and pregnancy rates after conventional in vitro fertilization and intracytoplasmic sperm injection. International Journal of Andrology. 2003; 26 (5): 279–285. DOI: 10.1046/j.1365-2605.2003.00424.x.

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Philip Vatcanarat Baysah, Aloysius Obinna Ikwuka, Francis Chigozie Udeh, Darius Popo Bleh, Thamara Viloria. (2023). Pathophysiological Effects of Alcohol and Tobacco Consumption on Semen Parameters of Men Attending a Fertility Clinic in West Africa. American Journal of Biomedical and Life Sciences, 11(4), 73-81. https://doi.org/10.11648/j.ajbls.20231104.13

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Philip Vatcanarat Baysah; Aloysius Obinna Ikwuka; Francis Chigozie Udeh; Darius Popo Bleh; Thamara Viloria. Pathophysiological Effects of Alcohol and Tobacco Consumption on Semen Parameters of Men Attending a Fertility Clinic in West Africa. Am. J. Biomed. Life Sci. 2023, 11(4), 73-81. doi: 10.11648/j.ajbls.20231104.13

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Philip Vatcanarat Baysah, Aloysius Obinna Ikwuka, Francis Chigozie Udeh, Darius Popo Bleh, Thamara Viloria. Pathophysiological Effects of Alcohol and Tobacco Consumption on Semen Parameters of Men Attending a Fertility Clinic in West Africa. Am J Biomed Life Sci. 2023;11(4):73-81. doi: 10.11648/j.ajbls.20231104.13

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@article{10.11648/j.ajbls.20231104.13,
  author = {Philip Vatcanarat Baysah and Aloysius Obinna Ikwuka and Francis Chigozie Udeh and Darius Popo Bleh and Thamara Viloria},
  title = {Pathophysiological Effects of Alcohol and Tobacco Consumption on Semen Parameters of Men Attending a Fertility Clinic in West Africa},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {11},
  number = {4},
  pages = {73-81},
  doi = {10.11648/j.ajbls.20231104.13},
  url = {https://doi.org/10.11648/j.ajbls.20231104.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20231104.13},
  abstract = {Background: Alcohol and tobacco consumption are prevalent global habits. There is existing evidence linking these habits to male infertility, although the impact they have on male fertility and reproductive outcomes are yet to be exhaustively investigated. Aim: This study aimed to study the pathophysiological effects of alcohol and tobacco consumption on semen parameters of men attending a fertility clinic in West Africa. Materials and Methods: Semen samples were collected from 196 men who attend Medlink Clinic, Monrovia, Liberia and parameters including sperm volume, count, motility, and morphology were evaluated according to the WHO criteria. The Chi-square test (χ2) of the SPSS version 23 statistical software was used to test for hypotheses at a significance level of pResults: The mean age of the men was 37.8±10.3 years. 20.9% of the study participants abstain from alcohol and tobacco, 38.8% consume alcohol, and 40.3% consume tobacco. Among the study participants, 36 (18.4%) had normospermia, 74 (37.8%) had oligospermia, 8 (4.1%) had cryptozoospermia, 5 (2.6%) had azoospermia, 58 (29.6%) had asthenozoospermia, and 15 (7.7%) had teratozoospermia. However, 78.9% frequent alcohol consumers, 47.4% non-frequent alcohol consumers, 77.8% non-alcohol consumers, 89.8% tobacco smokers, and 69.6% non-tobacco smokers had poor semen quality. The hypotheses tested proved that there is a significant relationship (p=0.024) between alcohol/tobacco consumption and poor semen quality, whereas there is no significant relationship (p=0.56) between non-consumption of alcohol/tobacco and good semen quality. There is also a significant relationship (p=0.0086) between alcohol consumption only and poor semen quality. Conclusion: Alcohol and tobacco consumption reduce male sperm quality, but abstinence from both does not guarantee optimum semen quality. Alcohol and/or tobacco consumption adversely affect the semen parameters (sperm volume, count, motility, and morphology).},
 year = {2023}
}

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T1  - Pathophysiological Effects of Alcohol and Tobacco Consumption on Semen Parameters of Men Attending a Fertility Clinic in West Africa
AU  - Philip Vatcanarat Baysah
AU  - Aloysius Obinna Ikwuka
AU  - Francis Chigozie Udeh
AU  - Darius Popo Bleh
AU  - Thamara Viloria
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DO  - 10.11648/j.ajbls.20231104.13
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SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.20231104.13
AB  - Background: Alcohol and tobacco consumption are prevalent global habits. There is existing evidence linking these habits to male infertility, although the impact they have on male fertility and reproductive outcomes are yet to be exhaustively investigated. Aim: This study aimed to study the pathophysiological effects of alcohol and tobacco consumption on semen parameters of men attending a fertility clinic in West Africa. Materials and Methods: Semen samples were collected from 196 men who attend Medlink Clinic, Monrovia, Liberia and parameters including sperm volume, count, motility, and morphology were evaluated according to the WHO criteria. The Chi-square test (χ2) of the SPSS version 23 statistical software was used to test for hypotheses at a significance level of pResults: The mean age of the men was 37.8±10.3 years. 20.9% of the study participants abstain from alcohol and tobacco, 38.8% consume alcohol, and 40.3% consume tobacco. Among the study participants, 36 (18.4%) had normospermia, 74 (37.8%) had oligospermia, 8 (4.1%) had cryptozoospermia, 5 (2.6%) had azoospermia, 58 (29.6%) had asthenozoospermia, and 15 (7.7%) had teratozoospermia. However, 78.9% frequent alcohol consumers, 47.4% non-frequent alcohol consumers, 77.8% non-alcohol consumers, 89.8% tobacco smokers, and 69.6% non-tobacco smokers had poor semen quality. The hypotheses tested proved that there is a significant relationship (p=0.024) between alcohol/tobacco consumption and poor semen quality, whereas there is no significant relationship (p=0.56) between non-consumption of alcohol/tobacco and good semen quality. There is also a significant relationship (p=0.0086) between alcohol consumption only and poor semen quality. Conclusion: Alcohol and tobacco consumption reduce male sperm quality, but abstinence from both does not guarantee optimum semen quality. Alcohol and/or tobacco consumption adversely affect the semen parameters (sperm volume, count, motility, and morphology).
VL  - 11
IS  - 4
ER  -

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Philip Vatcanarat Baysah

College of Medicine and Health Sciences, American International University West Africa, Banjul, The Gambia
Aloysius Obinna Ikwuka

College of Medicine and Health Sciences, American International University West Africa, Banjul, The Gambia
Francis Chigozie Udeh

College of Medicine and Health Sciences, American International University West Africa, Banjul, The Gambia
Darius Popo Bleh

Department of Laboratory Services, Medlink Clinic, Monrovia, Liberia
Thamara Viloria

College of Clinical Embryology and Artificial Reproduction Technology, University of Valencia, Valencia, Spain

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Philip Vatcanarat Baysah, Aloysius Obinna Ikwuka, Francis Chigozie Udeh, Darius Popo Bleh, Thamara Viloria. (2023). Pathophysiological Effects of Alcohol and Tobacco Consumption on Semen Parameters of Men Attending a Fertility Clinic in West Africa. American Journal of Biomedical and Life Sciences, 11(4), 73-81. https://doi.org/10.11648/j.ajbls.20231104.13

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ACS Style

Philip Vatcanarat Baysah; Aloysius Obinna Ikwuka; Francis Chigozie Udeh; Darius Popo Bleh; Thamara Viloria. Pathophysiological Effects of Alcohol and Tobacco Consumption on Semen Parameters of Men Attending a Fertility Clinic in West Africa. Am. J. Biomed. Life Sci. 2023, 11(4), 73-81. doi: 10.11648/j.ajbls.20231104.13

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AMA Style

Philip Vatcanarat Baysah, Aloysius Obinna Ikwuka, Francis Chigozie Udeh, Darius Popo Bleh, Thamara Viloria. Pathophysiological Effects of Alcohol and Tobacco Consumption on Semen Parameters of Men Attending a Fertility Clinic in West Africa. Am J Biomed Life Sci. 2023;11(4):73-81. doi: 10.11648/j.ajbls.20231104.13

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@article{10.11648/j.ajbls.20231104.13,
  author = {Philip Vatcanarat Baysah and Aloysius Obinna Ikwuka and Francis Chigozie Udeh and Darius Popo Bleh and Thamara Viloria},
  title = {Pathophysiological Effects of Alcohol and Tobacco Consumption on Semen Parameters of Men Attending a Fertility Clinic in West Africa},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {11},
  number = {4},
  pages = {73-81},
  doi = {10.11648/j.ajbls.20231104.13},
  url = {https://doi.org/10.11648/j.ajbls.20231104.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20231104.13},
  abstract = {Background: Alcohol and tobacco consumption are prevalent global habits. There is existing evidence linking these habits to male infertility, although the impact they have on male fertility and reproductive outcomes are yet to be exhaustively investigated. Aim: This study aimed to study the pathophysiological effects of alcohol and tobacco consumption on semen parameters of men attending a fertility clinic in West Africa. Materials and Methods: Semen samples were collected from 196 men who attend Medlink Clinic, Monrovia, Liberia and parameters including sperm volume, count, motility, and morphology were evaluated according to the WHO criteria. The Chi-square test (χ2) of the SPSS version 23 statistical software was used to test for hypotheses at a significance level of pResults: The mean age of the men was 37.8±10.3 years. 20.9% of the study participants abstain from alcohol and tobacco, 38.8% consume alcohol, and 40.3% consume tobacco. Among the study participants, 36 (18.4%) had normospermia, 74 (37.8%) had oligospermia, 8 (4.1%) had cryptozoospermia, 5 (2.6%) had azoospermia, 58 (29.6%) had asthenozoospermia, and 15 (7.7%) had teratozoospermia. However, 78.9% frequent alcohol consumers, 47.4% non-frequent alcohol consumers, 77.8% non-alcohol consumers, 89.8% tobacco smokers, and 69.6% non-tobacco smokers had poor semen quality. The hypotheses tested proved that there is a significant relationship (p=0.024) between alcohol/tobacco consumption and poor semen quality, whereas there is no significant relationship (p=0.56) between non-consumption of alcohol/tobacco and good semen quality. There is also a significant relationship (p=0.0086) between alcohol consumption only and poor semen quality. Conclusion: Alcohol and tobacco consumption reduce male sperm quality, but abstinence from both does not guarantee optimum semen quality. Alcohol and/or tobacco consumption adversely affect the semen parameters (sperm volume, count, motility, and morphology).},
 year = {2023}
}

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TY  - JOUR
T1  - Pathophysiological Effects of Alcohol and Tobacco Consumption on Semen Parameters of Men Attending a Fertility Clinic in West Africa
AU  - Philip Vatcanarat Baysah
AU  - Aloysius Obinna Ikwuka
AU  - Francis Chigozie Udeh
AU  - Darius Popo Bleh
AU  - Thamara Viloria
Y1  - 2023/08/05
PY  - 2023
N1  - https://doi.org/10.11648/j.ajbls.20231104.13
DO  - 10.11648/j.ajbls.20231104.13
T2  - American Journal of Biomedical and Life Sciences
JF  - American Journal of Biomedical and Life Sciences
JO  - American Journal of Biomedical and Life Sciences
SP  - 73
EP  - 81
PB  - Science Publishing Group
SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.20231104.13
AB  - Background: Alcohol and tobacco consumption are prevalent global habits. There is existing evidence linking these habits to male infertility, although the impact they have on male fertility and reproductive outcomes are yet to be exhaustively investigated. Aim: This study aimed to study the pathophysiological effects of alcohol and tobacco consumption on semen parameters of men attending a fertility clinic in West Africa. Materials and Methods: Semen samples were collected from 196 men who attend Medlink Clinic, Monrovia, Liberia and parameters including sperm volume, count, motility, and morphology were evaluated according to the WHO criteria. The Chi-square test (χ2) of the SPSS version 23 statistical software was used to test for hypotheses at a significance level of pResults: The mean age of the men was 37.8±10.3 years. 20.9% of the study participants abstain from alcohol and tobacco, 38.8% consume alcohol, and 40.3% consume tobacco. Among the study participants, 36 (18.4%) had normospermia, 74 (37.8%) had oligospermia, 8 (4.1%) had cryptozoospermia, 5 (2.6%) had azoospermia, 58 (29.6%) had asthenozoospermia, and 15 (7.7%) had teratozoospermia. However, 78.9% frequent alcohol consumers, 47.4% non-frequent alcohol consumers, 77.8% non-alcohol consumers, 89.8% tobacco smokers, and 69.6% non-tobacco smokers had poor semen quality. The hypotheses tested proved that there is a significant relationship (p=0.024) between alcohol/tobacco consumption and poor semen quality, whereas there is no significant relationship (p=0.56) between non-consumption of alcohol/tobacco and good semen quality. There is also a significant relationship (p=0.0086) between alcohol consumption only and poor semen quality. Conclusion: Alcohol and tobacco consumption reduce male sperm quality, but abstinence from both does not guarantee optimum semen quality. Alcohol and/or tobacco consumption adversely affect the semen parameters (sperm volume, count, motility, and morphology).
VL  - 11
IS  - 4
ER  -

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