We compared the benefit of modification in surgical technique in relation to primary prophylaxis of heterotopic ossifications after total hip replacement with straight stem. This modification contains the so-called electromyotomy technique and was compared versus standard „cold blade“ technique. Two groups were assessed and matched by BMI, sex, age and arthrosis type undergoing hip replacement. Traumatic, dysplastic and rheumatic hips were excluded. A total of 682 patients were evaluated, 262 cemented, 402 uncemented and 18 hybrid types with minimum of 1 year follow-up (average 5.6 years). The standard “sharp blade” technique contained 313 hips, the alternative contained 369 hips. Surgeries were performed according to the same protocols and by one team via anterolateral approach. Patients with risk factors for heterotopical ossifications and administration of secondary prophylaxis modalities were excluded. The development of heterotopic ossification were assessed with blind control of radiologic specialists (Brooker´s grades). Heterotopic ossification (HO) developed in 32.69%, totally in 223 patients. Of those clinically relevant (Brooker III and IV grades) were 8.94%, in 61 patients. In standard group there were 137 HO in 313 hips (43.76%), clinically relevant in 12.78%, 40 patients. In this group there were 123 cemented hips with 53 HO, 174 uncemented with 74 HO and 16 hybrid prostheses with 10 HO. Average age was 68.53 years, 153 males, 160 females. In alternative electromyotomy group there were 369 hips with 86 HO (23.30%), clinically relevant HO cases developed in 5.69%, 21 patients. HO in particular types: 139 cemented hips with 43 HO, uncemented 228 with 42 HO and hybrid 2 with 1 HO. Average age was 70.56y, males 171, females 198. Statistic values of HO occurence between these groups favourising the electromyotomy group were significant, such as comparing the particular Brooker grades distribution and prosthesis type (cemented, uncemented). Significant decrease was observed mainly in uncemented joint replacements and in clinically relevant grades in electromyotomy group. A novel perspective on primary prophylaxis of heterotopic hip ossification after straight femoral stem total hip replacement with engagement of modification in surgical technique so called electromyotomy is presented. Statistical analysis of results in ossification development significantly favorising modified technique in all types of prosthesis fixation, notably in uncemented prosthesis types. The main drop in counts of clinicaly relevant grades of osifications is also statistically relevant. According to these findings this surgical step is routinely implemented in our technique of straight stem implantations nowadays.
Published in | Journal of Surgery (Volume 9, Issue 5) |
DOI | 10.11648/j.js.20210905.15 |
Page(s) | 238-245 |
Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
Copyright |
Copyright © The Author(s), 2021. Published by Science Publishing Group |
Total Hip Replacement, Complications, Heterotopic Ossifications, Prophylaxis, Surgery Technique, Anterolateral Approach
[1] | Baird EO, Kang QK: Prophylaxis of heterotopic ossification - an updated review. J Orthop Surg Res. 2009; 4: 12. |
[2] | Biz C, Pavan D, Frizziero A, Baban A, Iacobellis C. Heterotopic ossification following hip arthroplasty: a comparative radiographic study about its development with the use of three different kinds of implants. J Orthop Surg Res. 2015; Nov 14 a10: 176. |
[3] | Cohn RM, Schwarzkopf R, Jaffe F. Heterotopic ossification after total hip arthroplasty. Am J Orthop. 2011 (Nov); 40 (11): E232-5. |
[4] | Debre J, Stepan Z, Dupal J.: Tranexamic acid reduces the incidence of heterotopic ossification after elective primary total hip prosthesis. Acta Chir Orthop Traumatol Cech. 2021; 88 (1) 13: 17. |
[5] | Forsberg JA, Potter BK, Polfer EM, SAfford SD, Elster EA. Do inflammatory markers portend heterotopic ossification and wound failure in combat wounds? Clin Orthop Relat Res. 2014; 472 (9): 2845-2854. |
[6] | Firoozabadi R, O´Mara TJ, Swenson A, Agel J, Beck JD, RouttM. Risk factors for the developmentof heterotopic ossification after acetabular fracture fixation. Clin Orthop Relat Res. 2014; 472 (11): 3383-8. |
[7] | Healy WL, Iorio R, Clair AJ, Pellegrini VD, Della Valle CJ et al.: Complications of total hip arthroplasty: Standardized list, definitions, and stratification developed by the hip society. Clin Orthop Relat Res 2016; 474: 357-364. |
[8] | Higo T, Mawatari M, Shigematsu M, Hotokebuchi T. The incidence of heterotopic ossification after cementless total hip arthroplasty. J Arthroplasty 2006; 21 (6): 852-856. |
[9] | Hrazdira I, Mornstein V. Medical biophysics and instrumentation. 1st edition. Brno: Neptune, 2001. p396. |
[10] | Hürlimann M, Schiapareli FF, Rotigliano N, Testa E, Amsler F et al.: Influence of surgical approach on heterotopic ossification after total hip arthroplasty - is minimal invasive better? A case control study. BMC Musculoskelet Disord. 2017 Jan; 21 a 18 (1): 27. |
[11] | Jaresova Ruzickova L.: Electrosurgical and low temperature procedures. Dermatol. Praxi. 2012; 6 (4): 200. |
[12] | Kremers HM, Lewallen EA, van Wijnen AJ, Lewallen DG. Clinical factors, Disease parameters, and Molecular Therapies Affecting Osseointegration of Orthopedic Implants. Curr Mol Biol Rep. 2016; 2 (3): 123-132. |
[13] | Lazard ZW, Olmsted-Davis EA, Gugala Z, Salisbury EA, Sonnet C, Davis EL, Beal E, Ubogu EE, Davis AR. Osteoblasts have neural origin in heterotopic ossification. Clin Orthop Relat Res. 2015; 473: 2790-2806. |
[14] | Litman GW, Rast JP, Fugmann SD. The origins of vertebrate adaptive immunity. Nat Rev Immunol. 2010; 10 (8): 543-553. |
[15] | Medici D., Olsen BR. The role of endothelial-mesenchymal transition in heterotopic ossification. J Bone Miner Res. 2012; 27: 1619-1622. |
[16] | Medici D, Shore EM, Lounev VY, Kaplan FS, Kalluri R, Olsen BR. Conversion of vascular endothelial cells into multipotent stem-like cells. Nat Med. 2010; 16: 1400-1406. |
[17] | Pape HC, Lehmann U, van Griensven M, Gansslen A, von Glinski S, Krettek C. Heterotopic ossifications in patients after severe blunt trauma with and without head trauma: incidence and patterns of distribution. J Orthop Trauma 2001; 15: 229-37. |
[18] | Pape HC, March S, Morley JR, Krettek C, Giannoudis PV. Current concepts in the development of heterotopic ossificaiotn J Bone Joint Surg Br 2004; 86-B: 783-7. |
[19] | Pavlou G, Salhab m, Murugesan L, Jallad S, Petsatodis G, West R, Tsiridis E. Risk factors for heterotopic ossification in primary total hip arthroplasty. Hip Int. 2012; 22: 50-55. |
[20] | Pennington N, Redmond A, Stewart T, Stone M. The impact of surgeon handedness in total hip replacement. Ann R Coll Surg Engl. 2014; 96 (6): 437-41. |
[21] | Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR. Multilineage potential of adult human mesenchymal stem cells. Science. 1999; 284: 143-147. |
[22] | Ranganathan K, Loder S, Agarwal S, Wong V, Forsberg J, Davis TA, Wang S, James AW, Levi B. Heterotopic ossification: Basic-Science Principles and Clinical Correlates. Curent Concepts Review. J Bone Joint Surg Am. 2015; 97: 1101-11. |
[23] | Salisbury EA, Lazard ZW, Ubogu EE, Davis AR, Olmsted-Davis EA. Transient brown adipocyte-like cells derive from peripheral nerve progenitors in response to bone morphogenetic protein 2. Stem Cells Transl Med. 2012 Dec; 1 (12): 874–85. |
[24] | Shore EM, Kaplan FS. Inherited human diseases of heterotopic bone formation. Nat Rev Rheumatol. 2010; 6 (9): 518-527. |
[25] | Sinha S, Uchibe K, Usami Y, Pacifici M, Iwamoto M. Effectiveness and mode of action of a combination therapy for heterotopic ossification with a retinoid agonist and an antiinflammatory agent. Bone. 2016; 90: 59-68. |
[26] | Suda RK, Billings PC, Egan KP, Kim JH, McCarrick-Walmsley R, Glaser DL, Porter DL, Shore EM, Pignolo RJ. Circulating osteogenic precursor cells in heterotopic bone formation. Stem Cells. 2009; 27 (9): 2209-2219. |
[27] | Van der Heide HJ, Rijnberg WJ, Van Sorge A, Van Kampen A, Schreurs BW. Similar effects of rofecoxib and indomethacin on the incidence of heterotopic ossification after hip arthroplasty. Acta Orthop. 2007; 78: 90-94. |
[28] | Wosczyna MN, Biswas AA, Cogswell CA, Goldhamer DJ. Multipotent progenitors resident in the skeletal muscle interstitium exhibit robust BMP-dependent osteogenic activity and mediate heterotopic ossification. J Bone Miner Res. 2012 May; 27 (5): 1004-17. |
[29] | Zeng LT, Zhu FB, Wang JY, Hou Q, Yue ZS, Yan SG, Quan RF, Zhang YL. Local influence of high molecular polyethylene particles on heterotopic ossification. Exp Ther Med. 2017; 13: 2934-2938. |
[30] | Zhu Y, Zhang F, Chen W, Zhang Q, Liu S, Zhang Y. Incidence and risk factors for heterotopic ossification after total hip arthroplasty: a meta- analysis. Arch Orthop Trauma Surg. 2015; 135: 1307-1314. |
APA Style
Jan Debre, Zdenek Stepan, Jiri Dupal, Jan Vanicek, Jan Potesil. (2021). Primary Prevention of Heterotopic Ossifications After Total Hip Replacement: Electromyotomy Technique. Journal of Surgery, 9(5), 238-245. https://doi.org/10.11648/j.js.20210905.15
ACS Style
Jan Debre; Zdenek Stepan; Jiri Dupal; Jan Vanicek; Jan Potesil. Primary Prevention of Heterotopic Ossifications After Total Hip Replacement: Electromyotomy Technique. J. Surg. 2021, 9(5), 238-245. doi: 10.11648/j.js.20210905.15
AMA Style
Jan Debre, Zdenek Stepan, Jiri Dupal, Jan Vanicek, Jan Potesil. Primary Prevention of Heterotopic Ossifications After Total Hip Replacement: Electromyotomy Technique. J Surg. 2021;9(5):238-245. doi: 10.11648/j.js.20210905.15
@article{10.11648/j.js.20210905.15, author = {Jan Debre and Zdenek Stepan and Jiri Dupal and Jan Vanicek and Jan Potesil}, title = {Primary Prevention of Heterotopic Ossifications After Total Hip Replacement: Electromyotomy Technique}, journal = {Journal of Surgery}, volume = {9}, number = {5}, pages = {238-245}, doi = {10.11648/j.js.20210905.15}, url = {https://doi.org/10.11648/j.js.20210905.15}, eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20210905.15}, abstract = {We compared the benefit of modification in surgical technique in relation to primary prophylaxis of heterotopic ossifications after total hip replacement with straight stem. This modification contains the so-called electromyotomy technique and was compared versus standard „cold blade“ technique. Two groups were assessed and matched by BMI, sex, age and arthrosis type undergoing hip replacement. Traumatic, dysplastic and rheumatic hips were excluded. A total of 682 patients were evaluated, 262 cemented, 402 uncemented and 18 hybrid types with minimum of 1 year follow-up (average 5.6 years). The standard “sharp blade” technique contained 313 hips, the alternative contained 369 hips. Surgeries were performed according to the same protocols and by one team via anterolateral approach. Patients with risk factors for heterotopical ossifications and administration of secondary prophylaxis modalities were excluded. The development of heterotopic ossification were assessed with blind control of radiologic specialists (Brooker´s grades). Heterotopic ossification (HO) developed in 32.69%, totally in 223 patients. Of those clinically relevant (Brooker III and IV grades) were 8.94%, in 61 patients. In standard group there were 137 HO in 313 hips (43.76%), clinically relevant in 12.78%, 40 patients. In this group there were 123 cemented hips with 53 HO, 174 uncemented with 74 HO and 16 hybrid prostheses with 10 HO. Average age was 68.53 years, 153 males, 160 females. In alternative electromyotomy group there were 369 hips with 86 HO (23.30%), clinically relevant HO cases developed in 5.69%, 21 patients. HO in particular types: 139 cemented hips with 43 HO, uncemented 228 with 42 HO and hybrid 2 with 1 HO. Average age was 70.56y, males 171, females 198. Statistic values of HO occurence between these groups favourising the electromyotomy group were significant, such as comparing the particular Brooker grades distribution and prosthesis type (cemented, uncemented). Significant decrease was observed mainly in uncemented joint replacements and in clinically relevant grades in electromyotomy group. A novel perspective on primary prophylaxis of heterotopic hip ossification after straight femoral stem total hip replacement with engagement of modification in surgical technique so called electromyotomy is presented. Statistical analysis of results in ossification development significantly favorising modified technique in all types of prosthesis fixation, notably in uncemented prosthesis types. The main drop in counts of clinicaly relevant grades of osifications is also statistically relevant. According to these findings this surgical step is routinely implemented in our technique of straight stem implantations nowadays.}, year = {2021} }
TY - JOUR T1 - Primary Prevention of Heterotopic Ossifications After Total Hip Replacement: Electromyotomy Technique AU - Jan Debre AU - Zdenek Stepan AU - Jiri Dupal AU - Jan Vanicek AU - Jan Potesil Y1 - 2021/10/19 PY - 2021 N1 - https://doi.org/10.11648/j.js.20210905.15 DO - 10.11648/j.js.20210905.15 T2 - Journal of Surgery JF - Journal of Surgery JO - Journal of Surgery SP - 238 EP - 245 PB - Science Publishing Group SN - 2330-0930 UR - https://doi.org/10.11648/j.js.20210905.15 AB - We compared the benefit of modification in surgical technique in relation to primary prophylaxis of heterotopic ossifications after total hip replacement with straight stem. This modification contains the so-called electromyotomy technique and was compared versus standard „cold blade“ technique. Two groups were assessed and matched by BMI, sex, age and arthrosis type undergoing hip replacement. Traumatic, dysplastic and rheumatic hips were excluded. A total of 682 patients were evaluated, 262 cemented, 402 uncemented and 18 hybrid types with minimum of 1 year follow-up (average 5.6 years). The standard “sharp blade” technique contained 313 hips, the alternative contained 369 hips. Surgeries were performed according to the same protocols and by one team via anterolateral approach. Patients with risk factors for heterotopical ossifications and administration of secondary prophylaxis modalities were excluded. The development of heterotopic ossification were assessed with blind control of radiologic specialists (Brooker´s grades). Heterotopic ossification (HO) developed in 32.69%, totally in 223 patients. Of those clinically relevant (Brooker III and IV grades) were 8.94%, in 61 patients. In standard group there were 137 HO in 313 hips (43.76%), clinically relevant in 12.78%, 40 patients. In this group there were 123 cemented hips with 53 HO, 174 uncemented with 74 HO and 16 hybrid prostheses with 10 HO. Average age was 68.53 years, 153 males, 160 females. In alternative electromyotomy group there were 369 hips with 86 HO (23.30%), clinically relevant HO cases developed in 5.69%, 21 patients. HO in particular types: 139 cemented hips with 43 HO, uncemented 228 with 42 HO and hybrid 2 with 1 HO. Average age was 70.56y, males 171, females 198. Statistic values of HO occurence between these groups favourising the electromyotomy group were significant, such as comparing the particular Brooker grades distribution and prosthesis type (cemented, uncemented). Significant decrease was observed mainly in uncemented joint replacements and in clinically relevant grades in electromyotomy group. A novel perspective on primary prophylaxis of heterotopic hip ossification after straight femoral stem total hip replacement with engagement of modification in surgical technique so called electromyotomy is presented. Statistical analysis of results in ossification development significantly favorising modified technique in all types of prosthesis fixation, notably in uncemented prosthesis types. The main drop in counts of clinicaly relevant grades of osifications is also statistically relevant. According to these findings this surgical step is routinely implemented in our technique of straight stem implantations nowadays. VL - 9 IS - 5 ER -