Clinical and Biological Effects and Quality of Life After Parathyroidectomy in Patients with Hyperparathyroidism Secondary to Chronic Renal Failure

Hadj Omar El Malki; Nisrine Hikki; Al Montacer Charif Chefchaouni; Lahcen Ifrine; Abdelkader Belkouchi; Loubna Benamar; Rabia Bayahia; Naima Ouzeddoun

doi:doi:10.11648/j.js.20221001.20

Clinical and Biological Effects and Quality of Life After Parathyroidectomy in Patients with Hyperparathyroidism Secondary to Chronic Renal Failure

Hadj Omar El Malki, Nisrine Hikki, Al Montacer Charif Chefchaouni, Lahcen Ifrine, Abdelkader Belkouchi, Loubna Benamar, Rabia Bayahia, Naima Ouzeddoun

Published in Journal of Surgery (Volume 10, Issue 1)

Received: 29 January 2022 Accepted: 17 February 2022 Published: 28 February 2022

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

Surgical treatment of hyperparathyroidism secondary to chronic renal failure still finds its place despite advances in dialysis and medical treatment. After a certain period of development, surgical management takes place on forms that are particularly symptomatic and resistant to medical treatment. The aim of our study is to evaluate the clinical and biological effects of parathyroidectomy and to correlate the results with a questionnaire on the quality of life. Through a retrospective study of 32 patients, operated over a period of 10 years in the Department of Surgery "A" of Ibn Sina Hospital in Rabat. We evaluated the clinical and biological effects of parathyroidectomy at the 3-year followup. The gesture achieved consists of parathyroidectomy 7/8e in the majority of cases after research and identification of the parathyroid glands. Postoperative hypocalcaemia was present in 22 cases (68.75%), and was symptomatic in 04 cases. Medium and long-term outcomes were satisfactory for the majority of patients clinically and biologically. The clinical improvement evaluated by a PAS (Parathyroidectomy Assessment of Symptoms) questionnaire before and one year after parathyroidectomy was statistically significant. Biologically, hematocrit improvement, decreased parathyroid hormone and alkaline phosphatase were statistically significant between 3 months and 3 years after parathyroidectomy.

Published in	Journal of Surgery (Volume 10, Issue 1)
DOI	10.11648/j.js.20221001.20
Page(s)	52-56
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Chronic Renal Failure, Secondary Hyperparathyroidism, Surgical Treatment, Quality of Life

References

[1]	Chin-Li Chen a, Shih-Hua Lin b, Jyh-Cherng Yu a, Ming-Lang Shih. A Persistent renal hyperparathyroidism caused by intrathyroidal parathyroid glands. Journal of the Chinese Medical Association 2014 Sep; 77 (9): 492-5.
[2]	Moe SM. Disorders involving calcium, phosphorus, and magnesium. Prim Care. 2008 Jun; 35 (2): 215-37.
[3]	Z. Skalli, H. Elouazzani, Z. Alhamany, M. Mattous, L. Benamar, R. Bayahia, M. Belkouchi, HadjOmar El Malki, N. Ouzeddoun. Kinetics of Parathyroid Hormone after Parathyroidectomy in Chronic Hemodialysis Patients. Saudi J Kidney Dis Transpl 2015; 26 (6): 1199-1204.
[4]	David A Bushinsky, Piergiorgio Messa. Efficacy of Early Treatment With Calcimimetics in Combination With Reduced Doses of Vitamin D Sterols in Dialysis Patients. NDT Plus. 2008 Jan; 1 (Suppl 1): i18-i23.
[5]	Puccini M, Ceccarelli C, Meniconi O, Zullo C, Prosperi V, Miccoli M, Urbani L, Buccianti P. Near Total Parathyroidectomy for the Treatment of Renal Hyperparathyroidism. Gland Surg. 2017 Dec; 6 (6): 638-643.
[6]	Pasieka JL, Parsons LL. A prospective surgical outcome study assessing the impact of parathyroidectomy on symptoms in patients with secondary and tertiary hyperparathyroidism. Surgery. Oct 2000; 128 (4): 531-9.
[7]	Pasieka JL, Parsons LL, Demeure MJ, Wilson S, Malycha P, Jones J, et al. Patient-based surgical outcome tool demonstrating alleviation of symptoms following parathyroidectomy in patients with primary hyperparathyroidism. World J Surg. août 2002; 26 (8): 942-9.
[8]	Jae Bok Lee, Woo Young Kim, and Yu-Mi Lee. The role of preoperative ultrasonography, computed tomography, and sestamibi scintigraphy localization in secondary hyperparathyroidism. Ann Surg Treat Res. 2015 Dec; 89 (6): 300–305.
[9]	Goldfarb M, Gondek SS, Lim SM, Farra JC, Nose V, Lew JI. Postoperative Hungry Bone Syndrome in Patients with Secondary Hyperparathyroidism of Renal Origin. World J Surg. 2012 Jun; 36 (6): 1314-1319.
[10]	Lau WL, Obi Y, Kalantar-Zadeh K. Parathyroidectomy in the Management of Secondary Hyperparathyroidism. Clin J AmSoc Nephrol. 2018; 13: 952–61.
[11]	Cheng SP, Lee JJ, Liu TP, Yang TL, Chen HH, Wu CJ, Liu CL. Parathyroidectomy improves symptomatology and quality of life in patients with secondary hyperparathyroidism. Surgery. 2014 Feb; 155 (2): 320-8.
[12]	M.-H. Lafage-Proust. Ostéodystrophie rénale. EMC (Elsevier Masson SAS, Paris), Appareil locomoteur, 14-275-A-10, 2008.
[13]	Yajima A, Tanaka K, Tominaga Y, Ogawa Y, Tanizawa T, Inou T, OtsuboO, Otsubo K. Early changes of bone histology and circulating markers of bone Turnover after parathyroidectomy in hemodialysis patients with severe hyperparathyroidism. Clin Nephrol. 2001 Jul; 56 (1): 27-34.
[14]	Gallieni, Brancaccio D. Which is the preferred treatment of advanced hyperparathyroidism in e renal patient? Medical intervention is the primary option in the treatment of advanced hyperparathyroidism in chronic renal failure. Nephrol Dial Transplant. 1994; 9 (12): 1816-9.
[15]	Kalle Landerholm, Anna-Maria Wasner, Johannes Järhult. Incidence and risk factors for injuries to the recurrent laryngeal nerve during neck surgery in the moderate-volume setting. Langenbecks Arch Surg. 2014 Apr; 399 (4): 509-15.
[16]	Matas Jakubauskas, Virgilijus Beiša, and Kęstutis Strupas. Risk factors of developing the hungry bone syndrome after parathyroidectomy for primary hyperparathyroidism. Acta Med Litu. 2018; 25 (1): 45–51.
[17]	Joerg Latus, Meike Roesel, Peter Fritz, Niko Braun, Christoph Ulmer, Wolfgang Steurer, Dagmar Biegger, M Dominik Alscher, Martin Kimmel. Incidence of and risk factors for hungry bone syndrome in 84 patients with secondary hyperparathyroidism. Int J Nephrol Renovasc Dis. 2013; 6: 131–137.

Cite This Article

Plain Text BibTeX RIS

APA Style

Hadj Omar El Malki, Nisrine Hikki, Al Montacer Charif Chefchaouni, Lahcen Ifrine, Abdelkader Belkouchi, et al. (2022). Clinical and Biological Effects and Quality of Life After Parathyroidectomy in Patients with Hyperparathyroidism Secondary to Chronic Renal Failure. Journal of Surgery, 10(1), 52-56. https://doi.org/10.11648/j.js.20221001.20

Copy | Download

ACS Style

Hadj Omar El Malki; Nisrine Hikki; Al Montacer Charif Chefchaouni; Lahcen Ifrine; Abdelkader Belkouchi, et al. Clinical and Biological Effects and Quality of Life After Parathyroidectomy in Patients with Hyperparathyroidism Secondary to Chronic Renal Failure. J. Surg. 2022, 10(1), 52-56. doi: 10.11648/j.js.20221001.20

Copy | Download

AMA Style

Hadj Omar El Malki, Nisrine Hikki, Al Montacer Charif Chefchaouni, Lahcen Ifrine, Abdelkader Belkouchi, et al. Clinical and Biological Effects and Quality of Life After Parathyroidectomy in Patients with Hyperparathyroidism Secondary to Chronic Renal Failure. J Surg. 2022;10(1):52-56. doi: 10.11648/j.js.20221001.20

Copy | Download

@article{10.11648/j.js.20221001.20,
  author = {Hadj Omar El Malki and Nisrine Hikki and Al Montacer Charif Chefchaouni and Lahcen Ifrine and Abdelkader Belkouchi and Loubna Benamar and Rabia Bayahia and Naima Ouzeddoun},
  title = {Clinical and Biological Effects and Quality of Life After Parathyroidectomy in Patients with Hyperparathyroidism Secondary to Chronic Renal Failure},
  journal = {Journal of Surgery},
  volume = {10},
  number = {1},
  pages = {52-56},
  doi = {10.11648/j.js.20221001.20},
  url = {https://doi.org/10.11648/j.js.20221001.20},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20221001.20},
  abstract = {Surgical treatment of hyperparathyroidism secondary to chronic renal failure still finds its place despite advances in dialysis and medical treatment. After a certain period of development, surgical management takes place on forms that are particularly symptomatic and resistant to medical treatment. The aim of our study is to evaluate the clinical and biological effects of parathyroidectomy and to correlate the results with a questionnaire on the quality of life. Through a retrospective study of 32 patients, operated over a period of 10 years in the Department of Surgery "A" of Ibn Sina Hospital in Rabat. We evaluated the clinical and biological effects of parathyroidectomy at the 3-year followup. The gesture achieved consists of parathyroidectomy 7/8e in the majority of cases after research and identification of the parathyroid glands. Postoperative hypocalcaemia was present in 22 cases (68.75%), and was symptomatic in 04 cases. Medium and long-term outcomes were satisfactory for the majority of patients clinically and biologically. The clinical improvement evaluated by a PAS (Parathyroidectomy Assessment of Symptoms) questionnaire before and one year after parathyroidectomy was statistically significant. Biologically, hematocrit improvement, decreased parathyroid hormone and alkaline phosphatase were statistically significant between 3 months and 3 years after parathyroidectomy.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - Clinical and Biological Effects and Quality of Life After Parathyroidectomy in Patients with Hyperparathyroidism Secondary to Chronic Renal Failure
AU  - Hadj Omar El Malki
AU  - Nisrine Hikki
AU  - Al Montacer Charif Chefchaouni
AU  - Lahcen Ifrine
AU  - Abdelkader Belkouchi
AU  - Loubna Benamar
AU  - Rabia Bayahia
AU  - Naima Ouzeddoun
Y1  - 2022/02/28
PY  - 2022
N1  - https://doi.org/10.11648/j.js.20221001.20
DO  - 10.11648/j.js.20221001.20
T2  - Journal of Surgery
JF  - Journal of Surgery
JO  - Journal of Surgery
SP  - 52
EP  - 56
PB  - Science Publishing Group
SN  - 2330-0930
UR  - https://doi.org/10.11648/j.js.20221001.20
AB  - Surgical treatment of hyperparathyroidism secondary to chronic renal failure still finds its place despite advances in dialysis and medical treatment. After a certain period of development, surgical management takes place on forms that are particularly symptomatic and resistant to medical treatment. The aim of our study is to evaluate the clinical and biological effects of parathyroidectomy and to correlate the results with a questionnaire on the quality of life. Through a retrospective study of 32 patients, operated over a period of 10 years in the Department of Surgery "A" of Ibn Sina Hospital in Rabat. We evaluated the clinical and biological effects of parathyroidectomy at the 3-year followup. The gesture achieved consists of parathyroidectomy 7/8e in the majority of cases after research and identification of the parathyroid glands. Postoperative hypocalcaemia was present in 22 cases (68.75%), and was symptomatic in 04 cases. Medium and long-term outcomes were satisfactory for the majority of patients clinically and biologically. The clinical improvement evaluated by a PAS (Parathyroidectomy Assessment of Symptoms) questionnaire before and one year after parathyroidectomy was statistically significant. Biologically, hematocrit improvement, decreased parathyroid hormone and alkaline phosphatase were statistically significant between 3 months and 3 years after parathyroidectomy.
VL  - 10
IS  - 1
ER  -

Copy | Download

Author Information

Hadj Omar El Malki

Department of Surgey ‘A’, Ibn Sina Hospital, Mohammed V University, Rabat, Morrocco
Nisrine Hikki

Department of Nephrologiy-Dialysis-Renal Transplantation, Ibn Sina Hospital, Mohammed V University, Rabat, Morocco
Al Montacer Charif Chefchaouni

Department of Surgey ‘A’, Ibn Sina Hospital, Mohammed V University, Rabat, Morrocco
Lahcen Ifrine

Department of Surgey ‘A’, Ibn Sina Hospital, Mohammed V University, Rabat, Morrocco
Abdelkader Belkouchi

Department of Surgey ‘A’, Ibn Sina Hospital, Mohammed V University, Rabat, Morrocco
Loubna Benamar

Department of Nephrologiy-Dialysis-Renal Transplantation, Ibn Sina Hospital, Mohammed V University, Rabat, Morocco
Rabia Bayahia

Department of Nephrologiy-Dialysis-Renal Transplantation, Ibn Sina Hospital, Mohammed V University, Rabat, Morocco
Naima Ouzeddoun

Department of Nephrologiy-Dialysis-Renal Transplantation, Ibn Sina Hospital, Mohammed V University, Rabat, Morocco

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Hadj Omar El Malki, Nisrine Hikki, Al Montacer Charif Chefchaouni, Lahcen Ifrine, Abdelkader Belkouchi, et al. (2022). Clinical and Biological Effects and Quality of Life After Parathyroidectomy in Patients with Hyperparathyroidism Secondary to Chronic Renal Failure. Journal of Surgery, 10(1), 52-56. https://doi.org/10.11648/j.js.20221001.20

Copy | Download

ACS Style

Hadj Omar El Malki; Nisrine Hikki; Al Montacer Charif Chefchaouni; Lahcen Ifrine; Abdelkader Belkouchi, et al. Clinical and Biological Effects and Quality of Life After Parathyroidectomy in Patients with Hyperparathyroidism Secondary to Chronic Renal Failure. J. Surg. 2022, 10(1), 52-56. doi: 10.11648/j.js.20221001.20

Copy | Download

AMA Style

Hadj Omar El Malki, Nisrine Hikki, Al Montacer Charif Chefchaouni, Lahcen Ifrine, Abdelkader Belkouchi, et al. Clinical and Biological Effects and Quality of Life After Parathyroidectomy in Patients with Hyperparathyroidism Secondary to Chronic Renal Failure. J Surg. 2022;10(1):52-56. doi: 10.11648/j.js.20221001.20

Copy | Download

@article{10.11648/j.js.20221001.20,
  author = {Hadj Omar El Malki and Nisrine Hikki and Al Montacer Charif Chefchaouni and Lahcen Ifrine and Abdelkader Belkouchi and Loubna Benamar and Rabia Bayahia and Naima Ouzeddoun},
  title = {Clinical and Biological Effects and Quality of Life After Parathyroidectomy in Patients with Hyperparathyroidism Secondary to Chronic Renal Failure},
  journal = {Journal of Surgery},
  volume = {10},
  number = {1},
  pages = {52-56},
  doi = {10.11648/j.js.20221001.20},
  url = {https://doi.org/10.11648/j.js.20221001.20},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20221001.20},
  abstract = {Surgical treatment of hyperparathyroidism secondary to chronic renal failure still finds its place despite advances in dialysis and medical treatment. After a certain period of development, surgical management takes place on forms that are particularly symptomatic and resistant to medical treatment. The aim of our study is to evaluate the clinical and biological effects of parathyroidectomy and to correlate the results with a questionnaire on the quality of life. Through a retrospective study of 32 patients, operated over a period of 10 years in the Department of Surgery "A" of Ibn Sina Hospital in Rabat. We evaluated the clinical and biological effects of parathyroidectomy at the 3-year followup. The gesture achieved consists of parathyroidectomy 7/8e in the majority of cases after research and identification of the parathyroid glands. Postoperative hypocalcaemia was present in 22 cases (68.75%), and was symptomatic in 04 cases. Medium and long-term outcomes were satisfactory for the majority of patients clinically and biologically. The clinical improvement evaluated by a PAS (Parathyroidectomy Assessment of Symptoms) questionnaire before and one year after parathyroidectomy was statistically significant. Biologically, hematocrit improvement, decreased parathyroid hormone and alkaline phosphatase were statistically significant between 3 months and 3 years after parathyroidectomy.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - Clinical and Biological Effects and Quality of Life After Parathyroidectomy in Patients with Hyperparathyroidism Secondary to Chronic Renal Failure
AU  - Hadj Omar El Malki
AU  - Nisrine Hikki
AU  - Al Montacer Charif Chefchaouni
AU  - Lahcen Ifrine
AU  - Abdelkader Belkouchi
AU  - Loubna Benamar
AU  - Rabia Bayahia
AU  - Naima Ouzeddoun
Y1  - 2022/02/28
PY  - 2022
N1  - https://doi.org/10.11648/j.js.20221001.20
DO  - 10.11648/j.js.20221001.20
T2  - Journal of Surgery
JF  - Journal of Surgery
JO  - Journal of Surgery
SP  - 52
EP  - 56
PB  - Science Publishing Group
SN  - 2330-0930
UR  - https://doi.org/10.11648/j.js.20221001.20
AB  - Surgical treatment of hyperparathyroidism secondary to chronic renal failure still finds its place despite advances in dialysis and medical treatment. After a certain period of development, surgical management takes place on forms that are particularly symptomatic and resistant to medical treatment. The aim of our study is to evaluate the clinical and biological effects of parathyroidectomy and to correlate the results with a questionnaire on the quality of life. Through a retrospective study of 32 patients, operated over a period of 10 years in the Department of Surgery "A" of Ibn Sina Hospital in Rabat. We evaluated the clinical and biological effects of parathyroidectomy at the 3-year followup. The gesture achieved consists of parathyroidectomy 7/8e in the majority of cases after research and identification of the parathyroid glands. Postoperative hypocalcaemia was present in 22 cases (68.75%), and was symptomatic in 04 cases. Medium and long-term outcomes were satisfactory for the majority of patients clinically and biologically. The clinical improvement evaluated by a PAS (Parathyroidectomy Assessment of Symptoms) questionnaire before and one year after parathyroidectomy was statistically significant. Biologically, hematocrit improvement, decreased parathyroid hormone and alkaline phosphatase were statistically significant between 3 months and 3 years after parathyroidectomy.
VL  - 10
IS  - 1
ER  -

Copy | Download